Could something as simple as a toxin be the death knell of evolution? That’s the question today for Kevin’s guest Dr. Olen Brown. Dr. Brown is an expert in toxicology and has an impressive resume of degrees and studies. If anyone is qualified to speak about how unscientific evolution is, it’s him.

Today on Educate For Life, learn how toxins, enzymes, and even ATP, a simple cellular fuel, provide mountains of evidence that evolution is an impossibility. To learn more about Dr. Brown and his work check out his website and his CV.

  • Author of 4 books (2002, 2007, 2017, 2018), and 197 scientific papers (1960-2018). https://www.eurekalert.org/pub_releases/2018-07/bsp-taa071018.php
  • Invited reviewer for American Association for the Advancement of Science (AAAS) with published critiques of 60 books and films (1987- currently).
  • Managing Editor of Frontiers in Bioscience, an on-line Encyclopedia of Science and Medicine for the topic: Oxygen in Biology (2005- currently).
  • Invited reviewer for various scientific journals including: Chemical Research in Toxicology and more than a dozen other science publications (1970s- currently).
  • Invited peer reviewer for NIH, NIEHS, CDC, EPA, Superfund, ATSDR, AIBS, UIS, DEPSCoR, U.S. Dept. of Commerce, NIST; 42 events,117 programs (1986-currently).
  • Media Consultant for news programs (TV, radio, print): for weapons of mass destruction (2002-2003); ABC News, Medical Unit and local news for Novichok (nerve agent) (2018). https://soundcloud.com/user-690109217/dr-olen-brown-mu-professor-emeritus
  • Judge for approval of abstracts for Annual Meeting of Free Radical Biology and Medicine (2004- currently).

EDUCATION:

  • PhD, Microbiology, University of Oklahoma, Norman (1964).
  • MS, Bacteriology, University of Oklahoma, Norman (1960).
  • BS, Laboratory Technology, University of Oklahoma, Norman (1958).

CERTIFICATIONS:

  • Toxicology: Certified by examination as a Diplomate in Toxicology by the American Board of Toxicology (1989-present) with re-certifications by re-examinations in 1994, 1999, and 2004; recertification in 2009 and 2014 by contributing certification questions with examination waived (currently appointed for 5 years from 01-01-2015) and appointed in 2013 to the American Board of Toxicology Standard of Knowledge Committee.
  • Chemistry and Chemical Engineering: Fellow of the American Chemical Institute, National Certification Commission, American Institute of Chemists, with annual re-certifications, 1988-1994.
  • Forensics:  American Board of Forensic Examiners, 1995 only.

EXPERTISE (BROADLY IN THE LIFE SCIENCES):

  • Toxicology (General, Academic, Pharmacologic, Forensic, Regulatory).
  • Medical Sciences (Microbiology, Immunology, Bacteriology, Virology, Cell Physiology, Infectious Diseases, Cancer, Allergy, Mechanisms of diseases).
  • Microbiology (Medical, Molecular Biology, Veterinary Medical, and Environmental).
  • Environmental Biology (Hazardous Wastes; Air, Water and Soil Pollution).
  • Chemistry (Biochemistry, Analytical, Organic).
  • Veterinary Sciences (Cell Physiology, Mechanisms of Disease).
  • More than 100 scientific publications; over $6 million granted in research funds.
  • Peer reviewer (NIH, NIEHS, CDC, ATSDR, Superfund and others).
  • Consultant and expert witness (approximately 200 cases in over two dozen states, Canada, and the Bahamas.

EXPERIENCE (GUIDED BY INTELLIGENCE, PREPARATION AND PERSISTENCE):

  • Risk assessment and determination of causation (as distinguished from association) from exposure to toxic chemicals and bacteria, viruses, molds (fungi) and acute and chronic toxic, infectious, allergic, and inflammatory diseases.
  • Evaluation of the therapeutic and harmful effects of ethical drugs and the effects of alcohol and other drugs of abuse.
  • Toxicity of solvents [benzene, gasoline, chlorinated hydrocarbons, leaking underground storage tanks (LUSTs)], pesticides (herbicides, insecticides, rodenticides, and biocides), heavy metals (mercury, lead, iron, manganese, copper, and zinc), ozone and other air pollutants (as affected by EPA’s recent action to impose stricter limits): applications include: work-place, therapeutic, and environmental exposures.
  • Evaluation of human medical and veterinary medical devices and pharmaceuticals 
  • Special expertise for rebutting the science of the EPA’s recent (2009) declaration of carbon dioxide (CO2) as a health hazard.
  • All testimony and opinions rendered within Daubert and/or Frye standards.

SCIENTIFIC CITATION RECORD FOR PUBLISHED WORKS:

Analysis by Harzing’s Publish or Perish using Google Scholar and Microsoft data sets shows:

  • • Brown’s papers were cited 1,258 times by other scientists in their publications.
  • • The most highly cited paper was published in the Journal of Applied Physiology in 1990 and has been cited 268 times by other scientists.
  • • The second most highly cited paper was published in the Journal of Biological Chemistry in 1993 and has been cited 128 times by other scientists.
  • • The third most highly cited paper was published in 1976 in the Journal Nature and has been cited 104 times by other scientists.
  • • The fourth most highly cited paper was published in Lasers in Surgery and Medicine in 1991 and has been cited 85 times by other scientists.
  • • The fifth most highly cited paper was published in the Biochemical and Biophysical Research Communications in 1978 and has been cited 65 times by other scientists.
  • • The sixth most highly cited paper was published in Science in 1981 has been cited 57 times by other scientists.
  • • Brown’s h-index is 18 (this is a recognized index of the quality of the body of published work of a scientist and is defined as:  “A scientist has index h if h of his/her Np papers have at least h citations each, and the other (Np-h) papers have no more than h citations each” (Hirsch, 2005; see www.harzing.com). For Brown this means that 18 papers have been cited at least 18 times each.
  • • Brown’s top 8 papers have been cited an average of101 times each.
  • • Brown’s Hb-index is 48.56
  • • Brown has published in Science, Nature and the Journal of Biological Chemistry which are among the top 10 most highly indexed journals).

SCIENTIFIC INTEREST AREAS:

“Science and technology, and the various forms of art, all unite humanity in a single

interconnected system- Zhores Aleksandrovich Medvedev.”

  • The biology of oxygen including lung function in health and disease, cellular respiration, oxygen radical toxicity mechanisms and defenses with medical applications for mechanisms of toxicity of chemicals, radiation, and infectious, inflammatory and immune diseases including asthma, degenerative brain disorders, convulsions, and for deep water diving, exercise physiology, and hyperbaric therapy, as examples.
  • Pathogenic, allergic, and immunologic mechanisms of bacterial, viral and fungal diseases and mechanisms of action of antibiotics and other ethical drugs.
  • Toxicology of acute and chronically-acting chemicals including their effects on humans, other animals, and broadly in the environment.

Principal Research Areas: The Life Sciences, specifically: Microbiology, Toxicology and Biochemistry. My principal research areas are: oxygen free radicals, including cellular sites and biochemical mechanisms of oxidant-stress damage; mechanisms of adaptation to extreme environments and exercise stress; toxicity of and defenses (including superoxide dismutase) against oxygen, free radicals and redox-active chemicals including xenobiotics, herbicides, pesticides and pharmaceuticals; free radicals in hyperbaric oxygen-induced convulsions and degenerative brain disorders; the mechanisms of infectious diseases; and assessment, measurement and remediation of environmental pollution, especially odors.

Applications of My Research: My focus on basic research has aided understanding of: the mechanisms of action of drugs and other chemicals; cellular respiration; exercise physiology; oxygen therapy; asthma; deep-water diving; infectious and inflammatory processes; oxidant-stress mechanisms and defenses; poisoning by environmental chemicals; measurement of odor and other environmental pollutants; cardiac re-perfusion injury and plaque formation; aging; traumatic, inflammatory and degenerative brain disorders (Parkinson’s and Huntington’s diseases); and hyperbaric oxygen poisoning, especially convulsions and newborn eye and lung toxicity [Book published in 2017: Oxygen, the Breath of Life: Boon and Bane in Human Health, Disease, and Therapy  ISBN 978-1-68108-426-8.]

Most Significant Research Accomplishments: Scientists under my direction have:

  • • Discovered that specific enzymes including dihydroxyacid dehydratase and asparagine synthetase (of branched-chain amino acid and asparagine biosynthesis, respectively), protein A of the quinolinate synthetase complex, 3-hydroxyanthranilate oxidase and indole amine oxidase (superoxygenase), and kynurenine hydroxylase of NAD biosynthesis and the kynurenine pathway are highly oxidant-sensitive while most enzymes are not (comparatively) sensitive to oxygen, and published mechanistic studies of several enzymes in these pathways that are target sites of herbicides including Roundup.
  • • Discovered that oxidant stress induces expression of genetic stringency in sensitive bacteria; that nitrofurans and other redox-active compounds kill human malarial parasites in vitro.
  • • Discovered that carbon dioxide (CO2) deprivation is lethal for various microbes and contributed to understanding the metabolic role of CO2 at the cellular level.
  • • Developed (with others) the thesis that control of the concentration, chelation and oxidation states of iron in cells is a fundamental defense against oxidant-stress.
  • • Devised a test to measure the oxidant-stress capability of drugs and environmental and food chemicals.
  • • Developed the theory that convulsions from hyperbaric oxygen, and certain degenerative brain pathologies, are caused by specific disturbances in the kynurenine pathway that generate excess amounts of quinolinate, an NMDA receptor agonist and excitotoxin.
  • • With Babu V. Bassa published evidence that the abundance of leucine in proteins helps to explain why leucine is exceptionally useful, compared to other branched-chain amino acids, in restoring exercise-induced loss of muscle protein and in containing involuntary loss of muscle mass in cancer.
  • • Devised and applied techniques to assess odor from lagoons and other environmental sources and initiated research into methods of odor bioremediation.

SCIENTIFIC APPOINTMENTS

“Nothing is more dangerous than an idea, when it’s the only one we have- Alain.”

RESEARCH (UNIVERSITY OF MISSOURI, COLUMBIA):

2001- Research Professor, retired (awarded Emeritus status).

1996-2001: Research Professor, Dalton Cardiovascular Research Center (DCRC).

1968-2001: Research Investigator, Space Sciences Research Center (now DCRC).

1974-1978: Assistant Director, Space Sciences Research Center (now DCRC).

1967-1968: Research Associate, Space Sciences Research Center (now DCRD).

RESEARCH (UNIVERSITY OF OKLAHOMA, NORMAN):

1958-1962:  Research Assistant.

ACADEMIC (UNIVERSITY OF MISSOURI, COLUMBIA):

1987-1996: Professor of Biomedical Sciences, College of Veterinary Medicine.

1981-1996: Professor of Microbiology (now Department of Molecular Microbiology and

              Immunology), UMC School of Medicine.

1977-1996: Professor of Microbiology, College of Veterinary Medicine.

1970-1977: Associate Professor of Microbiology, College of Veterinary Medicine.

1970         : Assistant Professor of Microbiology, College of Veterinary Medicine.

1965-1970: Assistant Professor of Microbiology, School of Medicine.

1964-1965: Instructor of Microbiology, School of Medicine.

ACADEMIC (UNIVERSITY OF OKLAHOMA, NORMAN):

1963-1964: Special Instructor.

1960-1962: Teaching Assistant

LISTINGS, HONORS, SELECTIONS (All listings are by invitation, none are paid listings):

“An honest man’s word is as good as his bond.”

      Listings (none paid):

American Men and Women of Science, 11th through current edition.

Marquis Who’s Who in the World, 11th through current edition.

Marquis Who’s Who in America, 46th through current edition.

Marquis Who’s Who in Medicine and Health Care, 1st through current edition.

International Scholar’s Directory.

Marquis Who’s Who in the Mid-West.

Who’s Who in Veterinary Science and Medicine, 1st Edition.

Two Thousand Notable American Men, 1st and subsequent editions, 1992.

National Faculty Directory.

Martindale-Hubbell’s Directory of Legal Experts and Consultants.

Men of Achievement, 15th edition, 1991.

International Leaders in Achievement, 2nd edition, 1992.

The International Directory of Distinguished Leadership, 3rd – 5th editions.

5000 Personalities of the World, 3rd edition.

Who’s Who in American Education, 3rd edition, 1992-93.

Who’s Who in Science and Engineering, 1st- 4th editions, 1992-93 to present.

The Dictionary of International Biography, 50th annual collection.

Longman’s Who’s Who in Science.

Who’s Who Worldwide Registry, Inc., 1994-95 Editions.

EDITORIAL BOARDS: (1) Biomedical Letters, The Faculty Press, Cambridge, England, 1991- ; (2) Frontiers in Bioscience, an on-line Encyclopedia of Science and Medicine: Oxygen in Biology including Free radicals and apoptosis; relationships with glutathione, thioredoxin and the BLC family of proteins authored by Julia C. Kern and James P. Kehrer (2005-): managing editor since 2005, Editor since 2017. (3) CellBio, biological sciences journal.

INVITED REVIEWER FOR SCIENTIFIC JOURNALS:

List of Scientific Journals, as examples:

  • • Proceedings of the National Academy of Science.
  • • Analytical Biochemistry.
  • • Environmental Health Perspectives.
  • • American Journal of Physiology.
  • • Heart and Circulatory Physiology.
  • • Archives of Biochemistry and Biophysics.
  • • Free Radical Biology and Medicine.
  • • Biomedical Letters.
  • • Chemical Research in Toxicology.
  • • International Journal of Biomedical Science.
  • • And others.

EXAMPLES of Scientific Papers Reviewed in 2014-2015-2016-2017-2018:

  • • Hesperetin mitigates acrolein-induced aapoptosis in lung cells in vitro and in vivo.

July 5, 2018, Redox Report.

  • • Vector control and insecticidal resistance in African malaria mosquito Anopheles gambiae. tx-2017-00285m, 12 October, 2017 for Chemical Research in Toxicology.
  • • Reaction of Trimethyl sulfoxide… 2017. Chemical Research in Toxicology.
  • • The double-edged sword profile of redox signaling: oxidative events as molecular switches in the balance between cell physiology and cancer. Chemical Research in Toxicology. tx-2017-00311y, 2017.
  • • The relationships among the levels of oxidative and antioxidative parameters, FEV1and prolidase activity in COPD, for Redox Reports (2015).
  • • Evaluation of toluene and xylene toxicity on reproductive function in male rabbits. [Authors proprietary: MS was rejected for technical reasons.] Toxicology and Environmental Chemistry. (01-08-2015).
  • • Effect of silymarin on apoptosis in some organs of BALB/c fetuses. CellBio (2015).
  • • Visualization of nanofibrillar cellulose in biological tissues using a biotinylated carbohydrate binding module of beta-1.4-glycase. Vogel, Ulla, et al. Chemical Research in Toxicology (07-01-1015).
  • • Antagonism of acute sulfite poisoning in mice by nitrite anion without methemoglobinemia. Cronican, Andrew, et al. Chemical Research in Toxicology (02-16-2015).
  • • Identification and quantification of metabolites of the fungicide tebuconazole in human urine. Fustinoni, Silvia, et al. Chemical Research in Toxicology (08-28-2014).
  • • The mitochondrial pyruvate carrier and metabolic regulation. CellBio (2014).
  • • Reading on the move: A study of reading behavior of Smartphone users in China. Journal of the Association for Information Science and Technology (07-08-2014).

Reviewed for Chemical Research in Toxicology (American Chemical Society publication) in 2013:

Manuscript ID Title Type

Date Submitted Submitting Author

tx-2013-004424 Indomethacin inhibits activation of endothelial nitric oxide synthase (eNOS) in the rat kidney: possible role of this effect in the pathogenesis of indomethacin-induced adverse effects Article  28-Nov-2013  Jacob, Molly

tx-2013-00378p Autoimmune Hepatitis Induced by Immunization of Mice with Isoniazid-Modified Hepatic Proteins is Paradoxically Attenuated by Oral Administration of Isoniazid Article  08-Oct-2013  Uetrecht, Jack

tx-2013-00272y In Vitro Metabolism of the Flame Retardants Tris (1,3-dichloro-2-propyl) Phosphate (TDCPP) and Triphenyl Phosphate (TPP) by Human Liver Article  26-Jul-2013  Stapleton, Heather

tx-2013-002379 Mixture Effects of Benzene, Toluene, Ethylbenzene and Xylenes to Lung Carcinoma Cells via a Hanging Drop Air Exposure System Article  01-Jul-2013  Liu, Faye

tx-2013-00233p Complex interactions between dioxin-like and non-dioxin like compounds on in vitro cellular responses: Implications for identification of dioxin exposure biomarkers. Article  25-Jun-2013  O’Kane, Anthony

tx-2013-001623 On superoxide dismutase mimics, other mimics, antioxidants, prooxidants and related matters. Review  12-May-2013  Liochev, Stefan

tx-2013-00177n Hierarchical correlation-based classification on Mode of Action using time-dependent cellular response curves Article  12-May-2013  Huang, Biao

tx-2013-00085h Interaction of Keap1 Modified by 2-tert-Butyl-1,4-benzoquinone with GSH: Evidence for S-Transarylation Article  01-Mar-2013  Abiko, Yumi

tx-2013-000045 Microbial degradation of microcystins Review

Prior years (examples):

  • Dibenzofuran potentiates apoptosis via induction of oxidative stress and disruption of inter-mitochondrial membrane potential (delta ώ m) in HepG2 cells. Chemical Research in Toxicology (2012).
  • Quinone induced activation of Keap1/Mrf2 signaling by aspirin prodrug masquerades as nitric oxide. Dunlap, Tareisha, et al. Chemical Research in Toxicology (08-23-2012).
  • Mycotoxins- obscure threats from fungi with severe consequences. By Russell Patterson, et al. Chemical Research in Toxicology (2011).
  • • Indoleamine 2,3-dioxygenase and 3OH-kynurenine modifications are found in the neuropathology of Alzheimer Disease. Bonda, David J., et al. Redox Report (02-22-2010).
  • Disulfides as Cyanide Antidotes by Zottola, reviewed August 20, 2009 for Chemical Research in Toxicology.
  • • The Risks of Copper and Iron Toxicity during Aging in Humans. By G. Brewer for Chemical Research in Toxicology.
  • LC-MS/MS Assessment of Cytochrome P450 and UDP-Glucuronosyltransferase Contributions to the Warfarin Metabolome in Human Urine” by Dr. Moran. Published in Chemical Research in Toxicology (02- 24- 2009).
  • LC/MS Analysis of NAD Biosynthesis Using Stable Isotope Pyrimidine Precursors. J. Evans, Tao-Chin Wang, M.P. Heyes, and S.P. Markey, Laboratory of Neurotoxicology, National Institute of Mental Health, Bethesda, MD 20892.
  • • Analytical Biochemistry (an International Journal of Methods in the Biological Sciences).
  • • Effects of Systemic and CNS-Localized Inflammation on the Contributions of Metabolic Precursors to the L-Kynurenine and Quinolinic Acid Pools in Brain. T. Kita, P.F. Morrison, M. P. Heyes, and S. P. Markey, Laboratory of Neurotoxicity, National Institute of Mental Health, Division of Bioengineering and Physical Sciences and

       Health, Division of Bioengineering and Physical Sciences, ORS, NIH, Bethesda, MD.     

  • • Purification and Inactivation of 3-Hydroxyanthranilic Acid 3,4-Dioxygenase from Beef Liver, D. Nandi, E.S. Lightcap, Y.K. Koo, X. Lu, J. Quancard, and R.B. Silverman, Department of Chemistry and Department of Biochemistry, Molecular Biology and Cell Biology, Northwestern Univ., Journal of Neurochemistry: Evanston IL 60208. International Journal of Biochemistry and Cell Biology (2002).
  • Antioxidant enzymes stimulation  in Aspergillius parasiticus, by Lentinula edodes,

       inhibits aflatoxin production. Massimo Reverbere, et al, Dept de Biologia Vegetale,

      Universita Degli Studi, Largo Cristinadi Svezia, Roma for the journal of Free Radical

      Biology and Medicine.

  • • Identification and Characterization of Thiosemicarbazones with Anti-Fungal and Anti-Tumor Effects: Cellular Iron-Chelation Mediating Cytotoxic Activity, Chemical Research in Toxicology.
  • • Replication By-Pass of the Acreolein-Mediated Deoxyguanine DNA and protein cross-links by DNA Polymerases, Chemical Research in Toxicology.
  • Induction of apoptosis pathways in several cell lines following exposure to the marine algal toxin azaspiracid-1, Chemical Research in Toxicology.

ELECTED UNIVERSITY MEMBERSHIPS (UMC COLUMBIA):

  • Graduate Faculty: 1967-.
  • Area of Microbiology: 1970-.
  • Doctoral Faculty: on establishment in 1974 and reappointed: 1981, 86, 91, 96.
  • Molecular Biology Faculty: on establishment in 1986.

PROFESSIONAL AND HONOR SOCIETIES:  Current or former member: Top One Percent (I.Q.) Society, New York, NY; The Society of the Sigma Xi; International Society for the Study of Xenobiotics; Society of Toxicology; American Chemical Society; American Institute of Chemists (Fellow) and Professional Program Board Member, 1989-90; The Oxygen Society; American Heart Association; International Society of Exposure Analysis; Undersea Medical Association; National Space Society; International Platform Association; American Association for the Advancement of Science; Society of Microbiology  (and others).

SELECTED, SCHOLARLY ACTIVITIES

“In the fields of observation, chance favors only the mind that is prepared- Louis Pasteur”

For The Agency  for Toxic Substances and Disease Registry (ATSDR): Peer review of the ATSDR/DTHHS/ETB Toxicological Profile entitled: “1,2-Dichloropropane” (reviewed: 05-06-2018). ATSDR is an agency within the U.S. Department of Health and human Services. Toxicological Profiles are mandated by Congress for hazardous substances found at National Priorities List sites. They are reference guides for physicians and the general public with information including chemical and physical properties, sources of exposure, routes of exposure, minimal risk levels (acute, chronic and cancer), and health effects.

Missouri Senate Agriculture Committee Hearing, March , 2007, invited as participant and speaker for  Senate Bill 364 (a bill described a “bill that eliminates the uncertainty surrounding county health ordinances and makes it clear that agriculture should be regulate at the state and federal levels). I was invited by the Missouri Farm Bureau Federation, Charles E. Kruse president.

Society for Free Radical Biology and Medicine, invited judge for scientific abstracts for presentations at the annual meeting of the Society, each year from 2004-Present.

Invited Scientist in Residence (honorary, non-paid), Cancer Research Center, Research Laboratory Director, Dr. Abraham Eisenstark, Columbia, MO, 2007.

For the EPA by Eastern Research Group (ERG), 110 Hartwell Ave. Lexington, MA 02421-3136. Invited peer reviewer (August 29, 2008) for External Peer Review of the Draft Provisional Toxicity Value (PPRTV) Manuscript for o-Chloronitrobenzene developed for the Superfund Health Risk Technical Support Center (STSC). Provisional values for chronic and subchronic RfD and RfC, and provisional Cancer Oral Slope Factors were reviewed. [The U.S. EPA seeks comprehensive external peer review that evaluates the scientific justification, clarity and objectivity of the PPRTVs.]

For the EPA by Eastern Research Group (ERG), 110 Hartwell Ave. Lexington, MA 02421-3136. Invited peer reviewer (March 8, 2007) for External Peer Review of the Draft Provisional Toxicity Value (PPRTV) Manuscript for 4-Chlorobenzotrifluoride developed for the Superfund Health Risk Technical Support Center (STSC). Provisional values for RfD, RfC for cancer and provisional RfD value and subchronic/chronic p-RfC values were reviewed.

For the EPA by Eastern Research Group (ERG), 110 Hartwell Ave., Lexington, MA 02421-3136; invited peer reviewer for the External Peer Review of Bifenox July, 2006.

For the EPA by Eastern Research Group (ERG), 110 Hartwell Ave., Lexington, MA 02421-3136; invited peer reviewer for the External Peer Review of the Draft Provisional Peer-Reviewed toxicity Value (PPRTV) Manuscript for Iron and Compounds Developed for the Superfund Health Risk Technical Support Center (STSC), May, 2006.

NIEHS/NIH (National Institute of Environmental Health Sciences and National Institutes of Health). Extra Mural Research and Training, Scientific Review Branch, Research Triangle Park, NC 27709 Invited peer reviewer of certain applications in response to Superfund Basic Research and Training Program (SBRP) at Research Triangle Park, Fall, 2005 Review responsibilities included for combustion-generated nanoparticles, xenobiotics, asthma, free radicals, heavy metals, arsenic, vinyl chloride (other information proprietary).

For the ATSDR by Eastern Research Group (ERG), 110 Hartwell Ave., Lexington, MA 02421-3136. February, 2005 peer review of research relied on by the Agency for Toxic Substances and Disease Registry (ATSDR) Toxicological Profile for Tin. [Toxicological Profiles summarize and interpret data on the occurrence of adverse effects of chemicals commonly found at Superfund sites and the levels of exposure that may bring about these effects The primary audience is health professionals and the informed public.]

NIEHS/NIH (National Institute of Environmental Health Sciences and National Institutes of Health). Extra Mural Research and Training, Scientific Review Branch, Research Triangle Park, NC 27709. Invited peer reviewer of certain applications in response to Superfund Basic Research and Training Program (SBRP) at Research Triangle Park, Fall, 2004 (other information proprietary).

For the EPA by Eastern Research Group (ERG), 110 Hartwell Ave., Lexington, MA 02421-3136; invited peer reviewer for the Risk Assessment Papers for: Provisional Subchronic RfD, Subchronic and Chronic RfCs, and Feasibility for Derivation of a Provisional Toxicity Value for a Carcinogenicity Assessment for Chlorine for the Superfund Health Risk Technical Support Center, for the chemical Chlorine (CASRN 7782-50-5) April 9, 2004.

For the EPA by Eastern Research Group (ERG), 110 Hartwell Ave., Lexington, MA 02421-3136; invited peer reviewer for the Feasibility for Derivation of a Provisional Toxicity Value for a Subchronic or Chronic RfD for two chemicals: anilinobenzothiazole (1843-21-6) and for benzothiazole (95-16-9), for the U.S. Environmental Protection Agency’s National Center for Environmental Assessment (NCEA) for use by NCEA’s Superfund Health Risk Technical Support Center (03/02/2004).

For the EPA by Eastern Research Group (ERG), 110 Hartwell Ave., Lexington, MA 02421-3136; invited peer reviewer for the Provisional Toxicity Values Issue Papers for the Superfund Health Risk Technical Support Center, for the chemical: dimethylphenethylamine (phentermine) relative to RfD, RfC, and carcinogenicity (1/30/2004).

Peer Reviewer for Microbiology Fellowship Program, invited by the EPA for February 9, 2004, Washington D.C., but I was unable to attend

Society for Free Radical Biology and Medicine, invited judge for scientific presentations at the annual meeting, 2003.

Frontiers of Bioscience, invited to the Managing Editorial Board July 2003, with responsibility for submissions in the area of the biology of oxygen including basic sciences and medicine Frontiers of Bioscience is a peer reviewed biology and medical journal and virtual library on the Web [http://www.bioscience.org], dedicated to bringing up-to-date information in science to biologists and physicians

For the ATSDR by Eastern Research Group (ERG), 110 Hartwell Ave., Lexington, MA 02421-3136; August 8-21, 2003 Peer review of the Agency for Toxic Substances and Disease Registry (ATSDR) Draft Toxicological Profile for Tin (work assignment 39 under ATSDRA Contract 2000-1999-00058). [Toxicological Profiles summarize and interpret data on the occurrence of adverse effects of chemicals commonly found at Superfund sites and the levels of exposure that may bring about these effects. The primary audience is health professionals and the informed public.

For the ATSDR by Eastern Research Group (ERG), 110 Hartwell Ave., Lexington, MA 02421-3136; August 1-14, 2003. Peer review of the Agency for Toxic Substances and Disease Registry (ATSDR) Draft Toxicological Profile for Zinc (work assignment 39 under ATSDRA Contract 2000-1999-00058).

For the EPA by Eastern Research Group (ERG), 110 Hartwell Ave., Lexington, MA 02421-3136. Peer review of US Environmental Protection Agency’s provisional toxicity assessment issue paper for the Health Effects Assessment Summary Table (HEAST) for benzoic acid, July 15-31, 2003.

For the EPA by Eastern Research Group (ERG), 110 Hartwell Ave., Lexington, MA 02421-3136. Peer review of US Environmental Protection Agency’s provisional toxicity assessment issue paper for the Health Effects Assessment Summary Table (HEAST) for dichloroprop, July 15-31, 2003.

Media Consultant for various national and international news sources and programs (TV and print) including on-the-air, relative to weapons of mass destruction, 2002-2003.

For the EPA by Eastern Research Group (ERG), 110 Hartwell Ave., Lexington, MA 02421-3136. Peer review of US Environmental Protection Agency’s provisional toxicity assessment issue paper for the Health Effects Assessment Summary Table (HEAST) for o-Chloronitrobenzene, July 2002.

For the EPA by Eastern Research Group (ERG), 110 Hartwell Ave., Lexington, MA 02421-3136. Peer review of US Environmental Protection Agency’s provisional toxicity assessment issue paper for the Health Effects Assessment Summary Table (HEAST) for p-Chloronitrobenzene, July 2002.

For the EPA by Eastern Research Group (ERG), 110 Hartwell Ave., Lexington, MA 02421-3136. Peer review of US Environmental Protection Agency’s provisional toxicity assessment issue paper for the Health Effects Assessment Summary Table (HEAST) for 2-Nitroaniline, July 2002.

Fund for the Improvement of Postsecondary Education (FIPSE), peer reviewer, March 2002.

For the ATSDR by Eastern Research Group (ERG), 110 Hartwell Ave., Lexington, MA 02421-3136;05/10 to 05/15/2000; Peer review of the Agency for Toxic Substances and Disease Registry (ATSDR) Draft Medical Management Guideline on Ammonia, Task order 4 under ATSDRA Contract 2000-1999-00058.

For the NIEHS: Selected to peer review 10 Superfund Basic Research Program grant applications totaling more than $250 million dollars, Research Triangle Park, prior to and during meeting, September 24-28, 1999 The programs reviewed were: (1) Toxic Metals in the Northeast: From Biological to Environmental Implications, J. Hamilton, Principal Investigator (PI), Dartmouth Medical School; (2) Genetic/Epigenetic Susceptibility to Superfund Chemicals, M. Costa, PI, New York University School of Medicine; (3) Genetic Determinants of Metal Toxicity and Bioavailability, M. Lieberman, PI, Baylor College of Medicine; (4) Health Hazards from Groundwater Contamination, L. Fischer, PI, Michigan State University; (5) Detection, Bioavailability, and Health Effects of Metals, T. Meehan, PI, University of California, San Francisco; (6) Biomarkers of Exposure to Hazardous Substances, B. Hammock, PI, University of California, Davis; (7) Integrating Human and Ecological Health, R. Kendall, PI, Texas Tech University; (8) Birth Defects Induced by Hazardous Waste Substances, T. Knudsen, P. Thomas, PI. Jefferson University, Philadelphia, PA; (9) Health Effects and Biodegradation of Complex Mixtures, K. Dixon, PI, University of Cincinnati; (10) Neurotoxic Superfund Chemicals, H. Lowndes, PI, Rutgers- The State University of New Jersey

For the EPA by Eastern Research Group (ERG). Peer review of (draft) Risk Assessment Issue Paper: Derivation of RfD Derivation, and Evaluation of RfC and Cancer for 4,4′-dichlorobenzophenone (CASRN 90-98-2), dated 97-020/6-25-99, EPA contract 68-C6-0041, September 24, 1999.

For the EPA by Eastern Research Group (ERG). Peer review of documents in draft by EPA (Draft Issue Papers for dimethyl sulfide and methyl mercaptan) (EPA contract 68-C6-0041); June, 1999.

NIEHS peer reviewer for ARCH (Advanced Research Cooperation in Environmental Health Sciences). This was a series of 8 proposals comprised of multiple programs similar to Program Projects but designed to partner a historically black college or university with a traditionally research intensive university; March 24-25, 1999.

For the EPA by Eastern Research Group (ERG). Peer review of document (Breast Milk) relating to EPA’s Hazardous Waste Identification Rule Risk Assessment (Task No. 320, EPA contract 68-W5-0057); December, 1998.

University of Missouri Research Board. Ad hoc peer reviewer of a grant for redox-chemistry and biology, October, 1998.

For the EPA by Eastern Research Group (ERG), August 1998. Review of two internal proposals for the Environmental Protection Agency, having to do with ambient air toxin monitoring and exposure assessment in an industry-impacted community, and development and evaluation of new time-and health-related monitoring methods for PM 2.5 (air-borne particle) episode prediction.

American Institute of Biological Sciences (AIBS), 1444 Eye Street, N.W., Washington, D.C., March, 1998. Review of: Fermentation, Recovery, and Purification of the Hc Fragment of the Botulinum Neurotoxin from Pichia pastoris (continuation), for U.S. Army Medical Research and Material Command, Fort Detrick, MD, Michael M. Meagher, University of Nebraska, Lincoln.

MU School of Nursing: participant, focus group to develop older adult care.

Naval Medical Research and Development Command, Naval Medical Research Institute, Bethesda, MD, August, 1997. Review of: Milton J. Axley, The Role of Gene Expression in Hyperbaric Oxygen Tolerance.

American Institute of Biological Sciences (AIBS), 1444 Eye Street, N.W., Washington, D.C., October, 1997. Review of two proposals for the U.S. Army Medical Research and Materiel Command (AMRMC): (1) Stabilized Crystalline Organophosphorus Hydrolase for use as Additive in Topical Skin Protection, C. Govardhan, Altus Biologics, Inc.; (2) Development of Protective Agents Against Sulfur Mustard-Induced Skin Lesions, Uri Wormser, Hebrew University.

United Information Systems, Inc. Bethesda, Maryland, September, 1996: Peer review for USAMRMC of Breast Cancer Research Program of 56 proposals in the area of Clinical and Experimental Therapeutics (Idea Awards, Research with Translational Potential Awards, and Postdoctoral, Predoctoral and Sabbatical Awards), with specific responsibility for: (1) Charles P. Martucci, Ph.D., Strang Cancer Research Institute, NY, NY. Role of nitric oxide in breast cancer;  (2) Arpad A. Vass, Ph.D., Oak Ridge National Laboratory. A study of the inhibitory effects of a bacterial preparation on carcinoma cells; (3) David Scott Lind, M.D., University of Florida, Veterans Administration Medical Center and Cancer Liasion, Gainesville;  (4) Prashant JC. Department of Pharmaceutical Sciences, University of Maryland, Baltimore. Targeting breast tumors with redoxactive prodrugs; and (5) Miles P. Hacker, Department of Pharmacology, University of Vermont, Oligotrophic microbes as a source of erbB21 and erbB3 inhibitors for chemotherapy of breast cancer.

American Institute of Biological Sciences (AIBS), 1444 Eye Street, Washington, D.C., April, 1996: Review for USAMRMC of four proposals: (1) Jouni Uitto, MD, PhD, Thomas Jefferson University, “Mechanics and treatment of junctional epidermolysis bullosa: relevance to military readiness”; (2) Tamar Kadar, DSc., Israel Institute for Biological Research, “Skin injury associated with epidermolysis bullosa and its relation to sulfur mustard

Research and Development 100 Awards: Judge for categories of bioscience, safety equipment, environmental sciences and consumer products; March-November 1996 and 1999.

American Institute of Biological Sciences (AIBS), 1444 Eye Street, NW., Washington, D.C., February 2 to March 13, 1996 Participant on the Chemical Defense Peer Review panel to the USAMRMC, for the following projects: (1) Diagnosis and dosimetry of exposure to sulfur mustard: Development of standard operating procedures, further exploratory research on protein adducts, Hendrick P. Benscop, TNO Prins Maurits Laboratory, The Netherlands; (2) The effects of soman on the pulmonary surfactant system, William D. Currie, Duke University Medical Center; (3) Development of decontamination compounds for therapeutic use on chemical threat wounds, John R. Dankert, HBR Technologies, Hodge, Louisiana; (4) A rapid field method for the detection and quantification of thiodiglycol in urine, Daniel Ehntholt, Arthur D. Little, Inc.; (5) The cytoskeleton and ATP in sulfur mustard-mediated injury to endothelial cells and keratinocytes, Daniel B. Hinshaw, Ann Arbor Department of Veterans Affairs Medical Center; (6) The use of in vivo electron paramagnetic resonance of the skin to monitor exposure to toxic agents, Peter J. Kannam,  Advanced Device Technology, Inc.; (7) Origins of inhibition of cholinesterases by organophosphates, Ilkido M. Kovach, Catholic University of America; (8) Cloning, expression, and function of saxiphilin: development of saxitonin-binding proteins, Edward G. Moczdlowski, Yale University School of Medicine; (9) Implications of protein alkylation and proteolysis of vesication caused by sulfur mustard, Marijke A. E. Mol, TNO Prins Maurits Laboratory, The Netherlands; (10) Genetic predisposition for susceptibility of cholinergic defects under anti-cholinesterase treatment, Hermona Soreq, Hebrew University of Jerusalem; (11) Transgenic engineering of cholinesterase: tools for exploring cholinergic responses, Hermona Soreq, Hebrew University of Jerusalem; (12) Development of newer preventative and therapeutic measures against ocular damage by sulfur mustard, Shambhu D. Varma, University of Maryland at Baltimore

Science and Math Helpline, The Museum of Scientific Discovery, Harrisburg, Pennsylvania, unpaid consultant, February 1996-.

Kansas Defense 2000 DEPSCoR (Defense Experimental Program to Stimulate Competitive Research); August, 1995; review of research proposal submitted by University of Kansas.

NIEHS:  Peer review of 15 Superfund Basic Science Program Projects involving health effects, remediation, analysis, and detection of water and air borne environmental chemicals; October-November, 1994 at Research Triangle Park, North Carolina: (1) Toxicities of PCBs and PCB remediation products, University of Illinois, Urbana; (2) Lead organochlorines in New York City, Mount Sinai School of Medicine; (3) Multidisciplinary study of PCBs at Akwesasne, University of Albany; (4) Health effects and toxicology of urban hazardous chemicals, Johns Hopkins University; (5) Superfund chemicals: transport, metabolism, and toxicity, University of Kentucky; (6) Microbial detoxication/degradation of hazardous wastes, University of Cincinnati; (7) Superfund toxic substances: exposure and disease, Harvard University; (8) Environmental fate and human exposure to carcinogens, University of North Carolina, Chapel Hill; (9) Superfund Basic Research Center at Boston University, Boston University School of Public Health; (10) Monitoring hazardous waste sites with sentinel species, Louisiana State University; (11) Cornell Superfund Basic Research Education Program, Cornell University; (12) Bioremediation of Superfund Chemicals by white rot fungi, Utah State University; (13) Basic Sciences Superfund Program Project, University of Louisville; (14) Basic Sciences Superfund Program Project, Ana G. Menendez University; (15) Basic Sciences Superfund Program Project , Fort Valley State College.

U.S. Department of Commerce, National Institutes of Standards and Technology, peer review of 20 research proposals for the US Environmental Protection Agency (EPA), for the Environmental Technology Initiative program, FY 1995: (1) Verification of innovative air missions monitoring systems; (2) Demonstration and evaluation of… autonomous underwater vehicles for coastal pollution monitoring; (3) Verification testing… for (testing) underground storage tanks; (4) Verification of low NOx burners; (5) Catalysis for pollution prevention; (6) Comparison of fine resolution satellite imagery; (7) Verification of… particulate and gaseous air cleaners; (8) Environmental technology verification…; (9) Evaluation… of coatings…; (10) Acoustic sensing of buried pipelines; (11) Demonstration Project; (12) A database for improved by-product recovery in the mining industry; (13) Process simulation for pollution prevention in the primary lead smelting industry; (14) Cleaner alternatives to hexavalent chromium…; (15) Biofuels and transportation; (16) Establishment of an area-wide, computer based crop disease forecasting system; (17) Environmental considerations in chemical design…; (18) Environmental technology pollution prevention…; (19) Pollution prevention through electrotechnologies; and (20) Development of a multi-media environmental monitoring… system.

NIEHS Superfund Basic Research, fall, 1991, peer review for seven Program Projects: (1) “Methods to Detect and Predict Human Exposure to Toxic Chemicals”, N.Y. Univ.; (2) “Petroleum Wastes”, Tulane; (3) “Genetic Risks of Hazardous Compounds”, LSU; (4) “Structural Basis of Toxicological Activity”, U. Pittsburgh; (5) “Biomarkers of Exposure to Hazardous Substances”, UC-Davis; (6) “Chemical Environmental Problems Associated with Mining”, U. Nevada; (7) “Health Hazards from Groundwater Contamination”, Michigan State University.

NIEHS site visit for review of administrative aspects and scientific progress of the Superfund Basic and Applied Research Program Project: bioremediation using white rot fungi, of Dr. S. Aust at the Biotechnology Center, Utah State University, Logan, Utah, Oct. 29-30 (1990).

NIEHS site-visit peer review team member for SCOR Project Grant: Dr. J. Bonaventura, PI, Duke University Marine Laboratory, 1986 “Marine and Freshwater Biomedical Center Grant.”

NIH site-visit peer review team member:  Program Project Grant:  Dr. T. Wolf, PI, University of California, 1979 “A Study of Wound Healing and Wound Infection.”

American Association for the Advancement of Science, reviewer and critic for books, films, videos and computer web sites with 33 published reviews (1986-present) in Science Books and Films, published by AAAS, Washington, D.C.

American College Testing (ACT) program: question and test item writer for this not-for-profit organization providing assessment and financial aid services throughout the world to schools, professional associations, and government agencies to more than 2 million people and 30,000 agencies and institutions annually, 1990-92.

Medical College Admission Test (MCAT): questions and test items, 1990-92.

  Sabbatical leaves: 1986-87 and 1993-94.

YOU Seminar: Experience I, II, Teaching Assistant, and The Step Beyond, 1986.

Campus Writing Program Summer Workshop Participant: 1986.

Guest Lecturer, Ross University, St. Kitts, West Indies:  Virology, 6 weeks, summer

1984, and Microbiology, Toxicology and Pharmacology, summer, 1988.

Medical Mycology Short Course, University of Arkansas, Little Rock, summer 1970.

Member, Graduate Dean’s Peer Review Group to assist faculty in applications for grant funds, 1984-87.

Science Judge: 22nd International Science and Engineering Fair, Kansas City, May, 1971, and for the Missouri Academy of Sciences, May, 1978.

Controlled Substances Registration: United States Department of Justice, Washington, D.C. and State of Missouri, for analysis of Schedule I, II, III, IV, and V substances (currently inactive).

Participant, Assessing Environmental Health Risks, Equifax Environmental Health Risk Studies, 1225 I Street, Suite 1200, Washington, D.C (1990).

Registered with National Institute of Justice, National Criminal Justice Reference Service, Rockville, MD.

Reference Scientist: School of Journalism for scientific news articles.

Listed with: NIH/ADAMHA consultant file, through 1998.

Science Fair Judge: Columbia Home School Association, 2001.

EXPERT WITNESSING AND LEGAL CONSULTING EXPERIENCE

(Principal Cases since Mid-1980s)

“Never promise more than you can perform… It is a bad plan that admits of no modification”- Publilus Syrus.

It is my philosophy that scientists should contribute to efficiency, truth, and justice by testifying in court on matters within their expertise.

TOTALS BY CATEGORIES FOR CASE WORK:

  • • Approximately 222 recorded cases (30 criminal) in 29 states and 1 in Canada.
  • • Approximately 51% for defense.
  • • Approximately 49% for plaintiff.
  • • 20 trials (including 3 hearings before judges only).
  • • 16 trials for the defense.
  • • 4 trials for the plaintiff.
  • • 35 depositions.
  • • 19 depositions for the plaintiff.
  • • 16 depositions for the defense.

PRINCIPAL CONSULTING EXPERIENCE FOR CORPORATIONS, FEDERAL AGENCIES, AND UNIVERSITIES

“Perfection is not possible, excellence is- Anonymous.”

Corporate:

GLG Corporation: Evaluation of toxicological safety of crumb rubber for use in athletic fields and playgrounds. 2016- 2017.

Guideline: Evaluation of toxicity risks from Agent for Kimberly-Clark.

Calibra Medical, Inc. 220 Saginaw Rd., Redwood Calif. (Proprietary matter). 2009.

Proprietary: Veterinary Medical Preventative and Therapeutic Agent. 2009

Guideline: Proprietary client, evaluation of a proprietary matter in New York, NY, 2007-

Guideline: Proprietary evaluation of an air purifier with medical uses, August, 2006.

Guideline: Proprietary tin toxicity assessment (medical applications), 2005-

Guideline: Proprietary client, toxicity evaluation of a medical device, 2006-

Gerson Lehrman Group: Member of Council of Healthcare Advisors; decision making assistance to corporations, business government.

The Science Advisory Board: Member of online group of 5000 life scientists and physicians focused on emerging technologies.

Round Table Group: Member of a global consortium which is described as the world’s largest think tank of academic and industry experts.

Innocentive: Member of web-based group that responds to scientific R&D development challenges; including submission of rainwater collection methodology that reached final stage of competitive selection process for providing inexpensive collection of rainwater in Third World Countries..

ARCCA: Member for forensic engineering, medical, and litigation consulting for analysis and communication of complex issues.

Teltech Division of FIND/SVP [formerly (until July 2, 2003) Teltech Technical Knowledge Service, Minneapolis, MN]: Consulting for various companies relative to: proprietary matters for Weyerhaeuser (June, 2003); Bacillus thuringensis and genetically engineered medical applications (10/14/1992); catalase enzyme manipulations (10/15/1992); biofilters and their use in remediations of environmental organic contaminants (11/11 to11/13/1992); anti-oxidation of platinum cardiac implants (01/13 to 01/27/1993); proprietary client regarding vaccine development (02/04/1993); redox potential measurements in biological media 07/30 to 08/10/93); enzyme technology; quality control and safety (risk) assessment of a chemicals  (cyclohexanone, methyl ethyl ketone and tetrahydrofuran) used with a medical device 12/15 to 12/27/1993; control of  Legionnaires microbes 08/16 to 08/10/1993; odor control (01/28 to 01/31/1994); Penicillium contamination of food product (10/13/1994); odor control (11/23/1994); survival characteristics of bacteria (11/29/1994); dust mite antigen characterization and standardization (03/23/1995); optimization of culture medium for Clostridia (04/07/1995; tolerance of infants for oxygen therapy via a medical device (09/13 to 09/14/1995; odor assessment (09/19 to 09/25/1995; selective culture medium for Salmonella (02/20 to 02/21/1996); antimicrobial properties of silver (04/30 to 05/06/1998); immuno-reactivity of killed spores (06/08/1998); and odor control from spilled grain (01/06/1997); hair permanent preparations, outdoor toilets and cat litter boxes (06/03 to 06/04/1996); odor control at a meat by-product rendering plant (Hormel) (03/08/2000);and analytical methods for measuring dental odors (March, 2000). Sciences International, Inc., Alexandria, VA: Health and Environmental Risk Assessment for Fortune 500 firms (1990).

Adria Laboratories, Columbus, Ohio: Relative to the cancer chemotherapeutic Adriamycin (1981-82).

Norwich-Eaton Pharmaceuticals, Norwich, NY: Relative to nitrofuran derivatives (antibiotics). (1984).

Immunological Vaccines (IMMVAC), Inc., Columbia, MO: vaccines development and contract administration for lecturers for Ross University, St. Kitts, West Indies (1987-92).

Proprietary Clients: incinerator safety and safety of pesticides (1990); food safety (1991); microbiological and toxicological safety of a medical device (2009); toxicological safety of a medical device (2007); toxicological safety of a veterinary medical device (2008-2009); 2011 Toxicology of a veterinary medical therapy under development and testing.

Proprietary Subjects: R.J. Reynolds, Winston-Salem (1988), NC; Lab Support, Inc. (1994); Kohler Corp., Kohler, WI. (1994).

University:

Oak Ridge Associated Universities, Oak Ridge, TN., collaboration for redox-research problems (1989-90).

The Toxicology Center, University of Iowa, Iowa City, IA, assistance with grant preparation (1982).

Kansas Defense 2000 DEPSCoR, review of proposal (1995).

Ross University, St. Kitts, West Indies: guest lecturer with administrative duties (1984 and 1988).

Government and Institutes:

Carlton Turner, Director, Drug Abuse Policy Office, for President Ronald Reagan, The White House: unpaid consultation (1982).

Office of International Cooperation & Development, U.S.D.A.: Washington, D.C.  Consultant (1988-90).

NIH and NIEHS: peer review, 1979, 1986, 1990, 1991, 1994, 1995 (and currently).

American Institute of Biological Sciences: peer review, 1996-1997.

United Information Systems, Inc.: Bethesda, MD, peer review, 1996.

Eastern Research Group, Inc.: 1998-present.

U.S. Dept. Comm., Nat. Inst. Standards & Tech. (for the U.S. EPA) peer review, 1995.

  Office of Naval Research: grant peer review, 1997.

Doctors for Disaster Preparedness: 2001-present.

PRO BONO AND COMMUNITY:  “You Seminar” counseling trainer, Dallas Texas (conducted by Phil McGraw, now Dr. Phil of TV); Columbia Track Club secretary and treasurer; University of Missouri Big Eight Track race timer and official; scientific advisor for UMC science ethics case; focus group participant for School of Nursing; fund raiser for Rock Bridge High School athletic field, March of Dimes and United Way Campaigns, and scientific consulting related to legal cases for plaintiffs unable to pay.

PRINCIPAL RESEARCH SUPPORT (Direct plus Indirect Costs)

“Remember, in the bacon and egg sandwich the egg is involved but the pig is committed- anonymous”

National Institute of Environmental Health Sciences, Toxicology Study Section, Principal Investigator, “Cellular Free Radical Toxicity Mechanisms,”4/1/81 through 2/28/89 (40% FTE), $696,813; competing renewal 3/1/89 through 2/28/94, (50% FTE), $768,690; competing renewal 9-30-95 through 9-29-00 (50% to 55% FTE, $730,715 direct ($1,062,823 total).

National Institutes of Health, Training Grant Co-Investigator (P.I., R. Finkelstein), DHHS. S-T32-AI07276-06, “Molecular Aspects of Microbial Pathogenesis”, 9-1-92 through 8-31-93, $183,786 direct and $194,778 total, and for entire period, (9-1-92 through 8-31-97), $990,181 direct and $1,049,405 total.

American Heart Association, The Effect of Glutathione monoethyl Ester Pretreatment on Heart Function During Endotoxin Shock; 7/1/95 to 6/30/96; stipend/supplies for Lillian Novela-Gilsdorf, 12,000.

National Institutes of Health, Blood, Heart and Lung Institute, Co-Investigator (H. Laughlin, PI):  “Training:  Muscle Blood Flow and Capillary Dynamics”, 12/1/88 through 11/30/93, (10% FTE), $982,366.

National Institute of Dental Health, Consultant (C. Reddy, PI) “Mechanism of Cleft

Palatogenesis by Secalonic Acid D”, 5/1/89 through 4/30/92, (5% FTE), $75,000.

Oak Ridge Associated Universities, research travel funds for travel to Oak

Ridge National Laboratory for collaborative endeavor with Dr. Howard Adler, 1988-1990.

Agency for International Development, Co-Investigator (Ted Green, PI) “Malaria Immunity and Immunization”, 9/30/83 through 9/29/86, (35% FTE), $1,328,852.

National Institutes of Health, Blood, Heart, and Lung Institute, Co-Investigator (Pat

Harris, PI): “Cardiovascular Control,” Training Grant, 7/1/76through 6/30/88, (5% FTE), $459,282.

Office of Naval Research, Contract, Principal Investigator (20% FTE): “Cellular

Mechanisms of Oxygen Toxicity”, 1/1/68 through 9/31/81; $280,000.

OTHER RESEARCH

“Ignorance never settles a question- Benjamin Disraeli.”

  • EXTRAMURAL COLLABORATIVE RESEARCH (Examples):  Dr. Dennis Flint, The DuPont Corporation, Wilmington, Delaware; Dr. James Fee, University of California at San Diego; Dr. Craig Lunte, Univ. of Kansas; J. R. Moffett, Georgetown University, Washington, D.C.; and Dr. Fong, Regional Mass Spectrometry Laboratory, Washington University, St. Louis; Dr. Ronald Grigsby, BDM Corp., Bartlesville, Oklahoma.
  • INTRAMURAL COLLABORATIVE RESEARCH (Examples):  Abraham Eisenstark, Biological Sciences, and Director of Cancer Research Center, stress defenses of Escherichia coli; and Albert Sun, Department of Pharmacology, Medical School, oxidant toxicity mechanisms and Parkinson’s disease.

SELECTED, INVITED PRESENTATIONS/PARTICIPATIONS at NATIONAL and INTERNATIONAL CONFERENCES, SYMPOSIA, and WORKSHOPS

“It is impossible to dissociate language from science or science form language. Lavoisier.”

  • • Sixth Annual Meeting of the Oxygen Society, presentation of the poster: Oxygen and Indoleamine or Tryptophan 2, 3- Dioxygenase of the Kynurenine Pathway by William Dale, November, 1999.
  • • Sixth Annual Meeting of the Oxygen Society, presentation of the poster: Hyperbaric Oxygen and Kynurenine Pathway Intermediates by William Dale, November, 1999.
  • • “American Society for Mass Spectrometry 1998 Meeting”, meeting attended by associate with presentation of co-authored poster, June, 1998.
  • • “Second International Oxidative Stress and Brain Damage Symposium”, Chicago, Ill., Sept., 1997.
  • • “Second International Meeting on Oxygen/Nitrogen Radicals and Cellular Injury”, Sept., 1997.
  • • “Metals in Biology,” Gordon Research Conference, Ventura, CA, January, 1990.
  • • “Oxygen Radicals in Biology”, Gordon Research Conference, Ventura, CA, Feb.1989.
  • • “Development and Testing of a New Cigarette Which Heats Rather Than Burns Tobacco”, workshop sponsored by R.J. Reynolds and Gradient Corp., St. Louis, Mo., Oct. , 1988.
  • • “Biological Data for Pharmacokinetic Modeling and Risk Assessment”, workshop sponsored by International Risk Science Institute, U.S. EPA, Dow Chemical Co., American Industrial Health Council, American Petroleum Inst., Mobil Oil Corp., Proctor & Gamble, and Shell Oil, Asheville, NC, May, 1988.
  • • “Oxygen Free Radicals”, Gordon Research Conference, Santa Barbara, CA, Feb., 1987.
  • • “Biology of Oxygen Radicals: An Overview”, Chairman & Presenter in Session V: Oxygen Free Radicals in Health & Disease, American  Academy of Veterinary Pharmacology & Therapeutics, Lake Ozark, MO, June, 1986.
  • • “Metals in Biology”, Gordon Research Conference, Santa Barbara, CA, Jan., 1986.
  • • “Oxygen Radical Toxicity”, National Blood, Heart and Lung Institute’s Frontiers of Science Symposium:  Washington, DC, Dec., 1986.
  • • “Philosophic and Scientific Implications of Evolution”, Sigma-Xi invited speaker, Central Missouri State University, Warrensburg, March, 1984.
  • • “Cellular Redox Mechanism of Toxicity”, invited speaker, The Toxicology Center, University of Iowa-Iowa City, September, 1982.
  • • “Oxygen and Redox-Active Drugs: Shared Toxicity Sites”, invited Speaker, Symposium: The Role of Cellular Redox Balance in Toxicity, sponsored by Soc. of Toxicology, Boston, Feb., 1982.
  • • “Mechanisms of Toxicity of Selected Xenobiotics”, invited keynote speaker, Missouri Academy of Science Annual Meeting, April, 1982.
  • • “Philosophic and Scientific Implications of Evolution”, invited Panel Speaker for the Missouri Committee for the Humanities, UMC-St. Louis; November, 1982.
  • • “Cellular Sites and Mechanisms of Oxygen Toxicity”, invited participant for the VII International Congress of Hyperbaric  Medicine, Moscow, Russia; September, 1981.
  • • “Specific Enzymatic Sites and Cellular Mechanisms of Oxygen Toxicity”, invited participant for Conference on “Biochemical and Clinical Aspects of Oxygen,” Pingree Park Campus of Colorado State University, September, 1978.
  • • “Invited Panel on Oxygen Toxicity”, Navy-wide Symposium on High Pressure Biomedical Research, Naval Coastal Systems Laboratory, Panama City, Florida, March, 1976.
  • • “A Microbiologist Looks at Mars”, Central Methodist College, April 8, 1969 and Marillac College, St. Louis, MO, November, 1967.
  • • “The Living Cell”, Northwest State University, Maryville, MO, October, 1967.

POSTDOCTORAL FELLOWS TRAINED AND VISITING SCIENTISTS

“You cannot solve the problem with the same kind of thought that has created the problem. Albert Einstein.”

(1)  Nana Amiridze, Ph.D. and M.D.,  Neurosurgery, Thilisi Medical Institute, Georgia, USSR, and Residency in Neurosurgery at Burdenko Neurosurgical Institute in Moscow, Russia, Postdoctoral Fellow, 1997-1999.

(2)  Yuhong Dang, Ph.D., Molecular Science. Southern Illinois University, Postdoctoral Fellow to Research Associate 1996-2000; currently a scientific position in St. Louis.

(3)  Chunsheng Xia, Ph.D., Biochemistry. Southern Illinois University, Postdoctoral Fellow, 1996-97. Currently a scientific position in St. Louis.

(4)  Betty Blanchard, Ph.D., Physiology, University of Illinois, Postdoctoral Fellow, 1995-97. Current position unknown.

(5)  Bozena Draczynska-Lusiak, Ph.D.,  Bioorganic Chemistry, Agriculture Academy of Wroclaw, Postdoctoral Fellow to Research Associate, 1990-94. Currently a research position with the Medical School, University of Missouri.

(6)  Bassa Babu, Ph.D.,  Medical Biochemistry, University of Delhi; Postdoctoral Fellow to Research Associate, moved to Nephrology Research Labs, Dept. of Veterans Affairs, Long Beach, CA., 1990.

(7)  Smyk-Randall, Ph.D., Biochemistry, Southern Illinois University, Carbondale, IL; postdoctoral fellow, 1985-1990; obtained a position as research associate at the University at Chapel Hill, NC, and is currently with Health Decisions, LTD., Chapel Hill, N.C.

(8)  Tony Baumgartner, Ph.D., Cytogenetics, Postdoctoral Fellow, 1990;  obtained position as a Medical Technologist, Department of Pathology, University Hospital and Clinics, Columbia, MO.

(9)  Filippelli, F., Ph.D., Medicinal Chemistry, University of Iowa, Iowa City, Iowa; Postdoctoral Fellow, 1988-1989. Obtained a position as Assistant Professor, Drake University School of Pharmacy and Health Sciences, Des Moines, Iowa.

(10)  Siwecki, G., Ph.D., Agricultural Chemistry; (deceased); Postdoctoral Fellow, 1983.

(11)  Foudin, L., Ph.D., Fungal Genetics, Univ. of Georgia; Postdoctoral Fellow, 1978-79. Currently Health Scientist Administrator, National Institute for Alcohol Abuse and Alcoholism, Rockville, MD.

(12)  Charles Fisher, Ph.D., 1980; Visiting Scientist; current position unknown.

DISSERTATIONS AND THESES DIRECTED

“I believe that in the end the truth will conquer- John Wycliffe.”

(1)  R. Seither:  “Redox Mechanisms of Toxicity:  Paraquat, Nitrofurantoin, and Streptonigrin”, Ph.D., 1983. (Winner of award as best paper at Missouri Branch American Society for Microbiology, Kansas City, Missouri, April, 1982). Now Associate Professor, Department of Medicine, Medical College of Virginia, Richmond, Virginia.

(2)  Huda Amash:  “The Effects of Selected Free Radical Generating Agents on Metabolic Processes in Bacteria and Mammals”, Ph.D., 1983.  Became Assistant Professor, Department of Biology, College of Science, University of Baghdad, Al-Jadria, Iraq; now Head of Iraq Academy of Science.

(3)  Mike Heitkamp:  “Inhibition of NAD Biosynthesis by Paraquat”, M.S., 1980.  (Winner of award as best paper at Missouri Branch American  Society for Microbiology meeting jointly sponsored by Area of Microbiology, Fall, 1980.)  Now an Environmental Scientist, Monsanto Company, St. Louis, Missouri.

(4)  R. Seither:  “Induction of the Stringent Genetic Response in Escherichia coli by Hyperbaric Oxygen Poisoning”, M.S., 1979. (Winner of award as best paper at Missouri Branch American Society for Microbiology, Spring, 1979.)  Continued for the doctorate.

(5)  D. Boehme:  “Inhibition of Amino Acid Biosynthesis by Hyperoxia.” (Winner of award as best paper at Missouri Branch of the American Society for Microbiology meeting, Spring, 1976.) Program terminated without Ph.D.

(6)  R. Mathis:  “Effect of Hyperoxia on ATP Concentration in Escherichia coli”, M.S., 1974.  (Winner of Microbiology Area award as best paper in competition with M.S. and Ph.D. students in Microbiology, University of Missouri four campus system.) Mathis obtained the doctorate and has advanced in rank in the Department of Biology, Canissius College in Buffalo, New York.

(7)  J. Stees:  “Hyperoxia:  Effects on Fatty Acid Synthetase of Escherichia coli and Bakers’ Yeast”, Ph.D., 1972. Currently has a position in banking.

(8)  R. Brunker: “Effect of Hyperoxia on NAD(H) and NADP(H) in Escherichia coli”, M.S., 1971. Obtained the D.D.S. and is a practicing dentist.

(9)  H. Howitt: “Effect of Hyperoxia on Fatty Acid Synthetase in Escherichia coli”, M.S., 1971 (deceased).

(10)  J. Stees: “The Red Pigment of Nocardia corallina”, M.S., 1967 (Continued for doctorate with me).

(11)  D. Huggett: “Toxicity of Hyperoxia for Microbes”, M.S., 1967. Obtained doctorate and advanced to be Director, Quality Control, Immuno-U.S., Inc., Rochester, Michigan.

(12)  S. Reda “Permeability and Metabolic Changes in Nocardia corallina”, M.S. in 1966 and obtained an M.D. and is practicing medicine in Wheaton, Illinois.

GRADUATE DEGREE COMMITTEE SERVICE

“Truth exists, only falsehood has to be invented- Georges Braque.”

(1)  Roger L. Anderson, M.S., Aug., 1965, Frank Engley, mentor, Department of Microbiology, School of Medicine, thesis title: Inhibition and Selection of Streptococcus pyogenes; obtained doctorate and moved to the Center for Disease Control, Atlanta, Ga.

(2)  Shang Woo Hwang, M.S., May, 1966, Robert Wixom, mentor, Department of Biochemistry, thesis title: “Valine Biosynthesis in Clostridia”; obtained the Ph.D. in Pharmacology with Dr. Waisalait; moved to the Federal Department of Agriculture.

(3)  Michael P. Kiley, M.S., Aug. 1967, Joseph Parisi, mentor, Department of Microbiology, School of Medicine, thesis title: “Some Chemical Factors Affecting the Selection of Variants of Staphylococcus aureus”; and moved to the Center for Disease Control, Atlanta, Ga.

(4)  Augustine Joseph, M.S., May, 1969, Robert Wixom, mentor, Department of Biochemistry, thesis title: “Amino Acid Metabolism in Propionibacterium and Hydorgenomous”; and moved to the Quartermaster Corps., Nadick, Mass.

(5)  David Weddell, Ph.D., May, 1969, Area of Microbiology, Dr. Robert Marshall, mentor. Dissertation title: “Growth Stimulation of Pathogenic Micrococci by Factors in Digests of DNA and in Leukocytes of Milk”; and moved to become in charge of production development for Mid-American Dairymen, Springfield, IL.

(6)  Russell J. Semmaro, Ph.D., 1970, Robert Wixom, mentor, Department of Biochemistry, dissertation title: “Valine and Isoleucine Biosynthetic Enzymes in Photoorganotrophs”; obtained the M.D. in Ophthalmology; and established practice in Ithica, N.Y.

(7)  Russell Baskett, Ph.D., Aug., 1971, David Hentges, mentor, Department of Microbiology, School of Medicine, dissertation title: “Mechanism of Shigella Inhibition by Acetic Acid”; current position unknown.

(8)  Jeffrey Bruce Cooper, Ph.D., May, 1972, Allen W. Hahn, mentor, Department of Veterinary Medicine and Bioengineering, dissertation title: “Mechanism of Oxygen Reduction on Platinum in Saline and Effects of Interstitial Fluid”; obtained position as Associate Professor, Biomedical Engineering, Massachusetts General Hospital, Harvard, Massachusetts

(9)  Rial DeWitt Rolfe, Ph.D., May, 1978, David Hentges, mentor, Department of Medical Microbiology, dissertation title: “A Biochemical Basis of Obligate Anaerobiosis”; obtained position as Associate Professor of Microbiology, School of Medicine, Texas Tech. University Hospital and clinic, Lubbock, Texas.

(10)  Linda Austin-Martin, M.A., December, 1980, Department of Health and Physical Education, Ben R. Londeree, mentor, thesis title:  “The Effect of Training Intensities on Maximal Steady State Oxygen Consumption and Maximal Oxygen Consumption “, obtained a position as a fitness consultant in Phoenix, Arizona.

(11)  Fred Murdock, M.S., December, 1982, Food Science and Nutrition, Dr. Marion Fields, mentor; thesis title: “B-Vitamin Content of Corn Mean During Natural Fermentation”, completed doctorate and obtained position as Assistant Professor of Food Chemistry, University of Wisconsin.

(12)  Laphaviranit, Laddavan, Ph.D., May, 1982, Area of Microbiology, Dr. Robert Marshall, mentor, dissertation title: “Interaction of Protease Preparation from Pseudomonas fluorescence with Bovine Milk Xanthine Oxidase”; obtained position as Associate Professor of Biochemistry, Madel University, Bangkok, Thailand.

(13)  Thomas  P. LaFontaine, Ph.D., December, 1983, Department of Health and Physical Education, Ben R. Londeree, mentor, dissertation title: “The Effect of Intensity and Quantity on Exercise Training on the Aerobic and Anaerobic Thresholds”; became Director of Cardiovascular and Pulmonary Rehabilitation, Boone Hospital Center, Columbia, MO.

(14)  Mark Allen Smith, M.S., May, 1986, Department of Chemical Engineering, Rakesh K. Bajpai, mentor, thesis title: “Controlled Cultivation of Escherichia coli Through Regulation of the Oxygen Demand by Substrate Feeding”; obtained position with Eli Lilly, Indianapolis, IN.

(15)  Deborah A. Hoxworth, M.S., December, 1987, Department of Health and Physical Education, Ben R. Londeree, mentor, thesis title: “Caffeine’s Effect on Energy Substrate Systems During Cycling at Two Intensities”; obtained position with the Pritiken Center, Philadelphia, Pennsylvania.

(16)  Sudhir Samuel John Batchu, M.S., May, 1988, Department of Veterinary Microbiology, Theodore Green, mentor, thesis title: “Application of Monoclonal Antibodies as Drug Mediated Carriers in P. falciparum Erythrocytic Stage Cultures”; has a foreign M.D. and obtained a residency training at the University of Missouri.

(17)  Melissa  Stuart, Ph.D., May, 1989, Department of Veterinary Microbiology, Theodore Green, mentor, dissertation title: “The Protective Roles of Monoclonal Rheumatoid Factors in Immunity to Malaria”; obtained a postdoctoral fellowship with Wendel Burkholder, U.S.D.A. ARS Stored Product Insect Research Unit, Entomology Department, Russell Labs, Madison, Wisconsin.

(18)  Mark Basecka, Ph.D., May, 1992, Department of Health and Physical Education, Ben R. Londeree, mentor, dissertation title: “The Relationships Among Exercise Blood Lactate Response, Muscle Blood Flow, and Oxidative Adaptation to Endurance Training in the Rat”.  Current position unknown.

(19)  Se Yoon, M.S., August, 1993, Department of Chemistry, William Bunnelle mentor, Research topic: “Kinetic Studies of the Reduction of Ozonides by Phosphines.”  Current position unknown.

(20)  Lillian Novela, doctoral candidate whose program was terminated in Physiology in 1997.

(21)  Jeong Sook Kim-Han completed doctoral program in summer, 1998 in Pharmacology, with a dissertation related to Parkinson’s disease.  Current position unknown.

  • COURSES TAUGHT:  Morphology and Variation in Bacteria, Pathogenic Bacteriology (guest lecturer),Microbiology for Medical Students (team taught), Microbiology for Nurses (team taught), Veterinary Microbiology (team taught), Pharmacology (guest lecturer), Microbial Physiology, Physiological Chemistry (team taught), Veterinary Cellular and Molecular Biology (team taught), and Toxicology (guest lecturer).
  • COMMITTEE APPOINTMENTS:  Facilities Committee, Dalton Cardiovascular Research Center; Faculty Search Committee, Veterinary Biomedical Sciences; Promotion and Tenure Committee, College of Veterinary Medicine (Chairman); Faculty Council Task Force: Administrative Review, Campus-wide; Research and Development Committee, Medical Center; Planning Committee for Atmospheric and Earth Sciences, Campus-wide; Scholarship and Awards Committee, Medical Center; Membership Committee of the Society of the Sigma Xi; Developer/Chairman, Area of Microbiology Graduate Student Research Award; Manuscript Review and Editing Committee, Veterinary Medical School; School of Veterinary Medicine Bulletin Committee; Policy Committee, Dalton Research Center; Medical Center Animal Care Committee; Medical Safety and Subcommittee Chairman for Laboratory Safety; Graduate Fellowship Committee, Dalton Research Center; Engineering Services Committee (Chairman) Dalton Research Center; Campus Library Committee (Budget Subcommittee Chairman); University-wide Safety Committee; Campus Committee, Review of Research Involving Human Subjects (Vice-Chairman); Promotion and Tenure Committee, Department of Veterinary Microbiology; Doctoral Faculty Review Committee; Graduate Faculty Senate and Special Task Force for Administrative Overview, and Academic Affairs Subcommittee; Biomedical Sciences Departmental Promotion and Tenure Committee (Chairman).
  • PERSONAL INFORMATION:  Married to Pollyana J. (nee King) Brown, retired mental health counselor. Daughter Barbara Engler, Architect and Manager with Jacobs Engineering, St. Louis, MO.  Daughter Diana Allen, Field Mgr, Rivers and Trails Conservancy, National Parks Service, St. Louis, MO.  Son David G. Brown, attorney, Private Practice, Brown Law Office, Columbia, MO  Avocations:  previously long-distance (including marathon) running, track officiating, oil, painting and pencil drawing; and my religious preference is Baptist.

BIBLIOGRAPHY

“Science is the search for truth- it is not a game in which one tries to best his opponent; to do harm to others- Linus Pauling.”

As of January 17, 2012, Harzing (who provides a down-loadable program for calculating the impact of a scientist’s body of publications) listed 76 papers for me with an h-index of 14 based on 807 citations of my papers by other authors (this means that I have 14 papers that were cited 14 or more times each). The highest cited papers were cited: 166  times, 84 times, 58 times, 49 times, 37 times, two were cited 29 times, 26 times, 23 times, 22 times, 18 times, 16 times, 15 times, 14 times, 13 times, two were cited 12 times, three were cited 11 times, and other papers were cited a lesser numbers of times.

As of August 7, 2015, my score on Research Gate was 31.33 which is higher than 90% of Research Gate members. Research Gate is an on-line service, founded in 2008 by to physicians and a computer scientist. It now has more than 7 million members and their mission is to connect and make it easier for them to share and to access scientific output, knowledge, and expertise to advance scientific research. They self-describe Research Gate score as a new way to measure scientific reputation. The Research Gate score is based on publications by the individual scientist and how other scientists interact with that science content on Research Gate.

I have published peer reviewed papers in Science, Nature, and the Journal of Biochemistry; each has a highly-ranked impact factor (officially determined assessment of value to scientists). The 2015 impact factor for Nature was 41.456, which ranked number one of 56 in the category, Multidisciplinary Sciences; Science had an impact factor of 33.611; and the Journal of Biochemistry, 4.573.

Journal Papers:

(1)   Olen R. and Clark, J.B. Studies on the life cycle of Nocardia corallina.  Proc. Okla. Acad. Sci.  40:56-58 (1960).

(2)   Brown, Olen R. and Clark, J.B. The tricarboxylic acid cycle in Nocardia corallina.  Proc. Okla. Acad. Sci. 41:94-98 (1961).

(3) Brown, Olen R. Metabolism, Morphogenesis and Pigmentation in Nocardia corallina Dissertation 1964. [Note: I have listed my dissertation here because it is cited in Harzings and is available in the open literature.] [1]

(4)   Brown, Olen R. and Clark, J.B. Evidence for the Pentose Cycle in Nocardia corallina.  Proc. Soc. Exp. Biol. Med. 122:887-890 (1966).

(5)   Brown, Olen R. and Clark, J.B. Fragmentation in Nocardia corallina. J. Gen. Microbiol.  45:525-530 plus 4 plates (1966).

(6)   Brown, Olen R. and Clark, J.B. Pigment of Nocardia corallina. J. Bacteriol. 92:1844-1845 (1966).

(7)   Brown, Olen R. Instrumented Quantification of Live Bacteria in the Presence of Dead Cells.  Applied Microbiol. 14:1054-1055 (1966).

(8)   Brown, Olen R. and Reda, S. Enzyme and Permeability Changes during Morphogenesis of Nocardia corallina. J. Gen. Microbiol. 47:199-205 (1967).

(9)   Brown, Olen R., Silverberg, R., and Huggett, D.O. Synergism between Hyperoxia and Antibiotics for Pseudomonas aeruginosa. Applied Microbiol. 16:260-262 (1967).

(10)   Brown, Olen, R. and Huggett, D.O. Effects of Hyperoxia upon Microorganisms. l. Membrane Culture Techniques for Exposing Cells Directly to Test Atmospheres. Appl. Microbiol. 16:476-479 (1968).

(11) Silverberg, D.O. and Brown, O.R. Synergism between Hyperoxia and Antibiotics for Pseudomonas aeruginosa. Applied Microbiology 16(2) 1968.

(12)   Stees, J.L., Brown, O.R., and Grigsby, R.D. Structural Features of the Major Pigment Component of Nocardia corallina. Microbios. 2:199-200 (1969).

(13)   Brown, O.R. and Howitt, H.F. Growth Inhibition and Death of Escherichia coli from CO2 Deprivation.  Microbios 3:241-246 (1969).

(14)   Brown, O.R., Stees, J.L., Mills, D.F., Davis, R., and Major, S. Killing Kinetics of Escherichia coli in a Carbon Dioxide Deficient, Pure Oxygen Environment. Microbios. 3:267-272 (1969).

(15)   Brown, O.R., Howitt, H.F., Stees, J.L., and Platner, W. Effects of Hyperoxia on Composition and Rate of Synthesis of Fatty Acids in Escherichia coli. J. Lipid Research 12:692-698 (1971).

(16)   Brown, O.R. Resistance of Oxidative Phosphorylation in Escherichia coli to Hyperoxia. J. Bioenergetics 2:217-220 (1971).

(17)   Brown, O.R. and Barrett, E. Modification of a Fermentor for Pressurized Fermentation. Biotechnology and Bioengineering 13:703-707 (1971).

(18)   Brunker, R.L. and Brown, O.R. Effects of Hyperoxia upon Oxidized and Reduced NAD and NADP Concentrations in Escherichia coli. Microbios 4:193-203 (1971).

(19)   Brown, O.R. Correlations between Sensitivities to Radiation and to Hyperoxia in Microorganisms. Radiation Research 50:309-318 (1972).

(20)   Brown, O.R. Reversible Inhibition of Respiration in Escherichia coli. Microbios 5:7-16 (1972).

(21)   Brown, O.R. and Peterson, D. Sensitivity to Oxygen at High Pressure of Radioresistant and Radiosensitive Strains of Bacteria. Aerospace Medicine. 44:71-73 (1973).

(22)   Brown, O.R. Inhibition of Escherichia coli on Cellulose Acetate Membrane Filters. Microbios 7:235-240 (1973).

(23)   Stees, J.L. and Brown, O.R. Susceptibilities of Intracellular and Surface Sulphydryl Groups of Escherichia coli to Oxidation by Hyperoxia. Microbios 7:247-266 (1973).

(24)   Stees, J.L. and Brown, O.R. Stability of Yeast Fatty Acid Synthetase Component Enzymes to Irreversible Inactivation by Hyperbaric Oxygen. Microbios 8:247-256 (1973).

(25)   Brown, O.R., Dexter, J., and Yein, F. Bacterial Quantification in Wounds by an Isotopic Method. I.R.C.S. 2:1333 (1974).

(26)   Brown, O.R. Yeast Fatty Acid Synthetase:  A Proposed Binding Site for Coenzyme A with Consequences for Chain Initiation and Chain Termination. J. Theoretical Biology 47:137-144 (1974).

(27)   Brown, O.R. and Barton, J. Automated Instrument for Measuring Biological Transport Kinetics Over Intervals of a Few Seconds. Biotechnology and Bioengineering 16:1645-1657 (1974).

(28)   Brown, O.R. Failure of Lipoic Acid to Protect Against Cellular Oxygen Toxicity in Escherichia coli. Microbios. 14:205-217 (1975).

(29)   Brown, O.R. and Mathis, R.R. ATP Changes in Escherichia coli During Oxygen Toxicity.  I.R.C.S. 3:557 (1975).

(30)   Brown, O.R. Lethality of CO2 – Deprivation for Some Bacteria. I.R.C.S. 3:802 (1975).

(31)   Mathis, R.R. and Brown, O.R. ATP Concentration in Escherichia coli During Oxygen Toxicity. Biochimica et Biophysica Acta 440:723-732 (1976).

(32)   Brown, O.R. and Hines, M.B. Selective Toxicity of One Atmosphere of Oxygen during Morphogenesis of Two Lepidopterans. Aviation Space and Environmental Medicine 47:954-957 (1976).

(33)   Boehme, D.E., Vincent, K., and Brown, O.R. Oxygen Toxicity: Inhibition of Amino Acid Biosynthesis. Nature 262:418-420 (1976).

(34)   Brown, O.R. and Stees, J.L. Simple Assay for the Condensation Component Enzyme (ß-ketoacyl synthetase) of Fatty Acid Synthetase. Microbios 17:17-21 (1976).

(35)   Yein, F. and Brown, O.R. Comparative Inactivation of Yeast Fatty Acid Synthetase Component Enzymes by 100 Atmospheres of Oxygen. Biochimica et Biophysica Acta 486:421-428 (1977).

(36)   Brown, O.R., Yein, F., Mathis, R.R., and Vincent, K. Oxygen Toxicity: Comparative Sensitivities of Membrane Transport, Bioenergetics and Synthesis in Escherichia coli.  Microbios 18:7-25 (1977).

(37)   Brown, O.R. and Yein, F. Dihydroxyacid Dehydratase:  The Site of Hyperbaric Oxygen Poisoning in Branched-Chain Amino Acid Biosynthesis. Biochem. Biophys. Res. Comm. 85:1219-1224, (1978).

[38] Brown, O. R., F. Yein, and D. Boehme. Bacterial Sites of Oxygen Toxicity Potentially Common to Red Cells and Erythropoiesis. Progress in Clinical and Biological Science. The Red Cell, Proceedings 4th International Conference on Red Cell Metabolism and Function, Ed. by G.J. Brewer, Alan R. Liss, Pub., pp. 701-714 (1978).

(39)   Brown, O.R, and Yein, F. Sensitivity to and Site of Oxygen Poisoning in Escherichia coli. Fifth International Symposium on Intestinal Microecology, Ed. by D. Hentges and T.D. Lucky. American Journal of Clinical Nutrition 32:267 (1979).

(40)   Brown, O.R., Boehme, D., and Yein, F. Fructose l, 6-diphosphatase: A Cellular Site of Hyperbaric Oxygen Toxicity.  Microbios 23:175-192 (1979).

(41)   Brown, O.R., Yein, F., Boehme, D., Foudin, L., and Song, C.S. Oxygen Poisoning of NAD Biosynthesis:  A Proposed Site of Cellular Oxygen Toxicity. Biochemical and Biophysical Research Communications 91:982-990 (1979).

(42)   Brown, O.R. and Song, C.S. Pyridine Nucleotide Coenzyme Biosynthesis:  A Cellular Site of Oxygen Toxicity. Biochem. Biophys. Res. Commun. 93:172-178 (1980).

(43)   Brown, O.R., Gilliland, P.L., Lees, A.C., Fee, J.A., Block, P.L., and Neidhardt, F.C. Oxygen Stasis of Bacterial Growth:  Analogy between the Stasis of E. coli by Hyperbaric Oxygen and by Paraquat. Biochem. International 1:304-311 (1980).

(44)   Brown, O.R., Heitkamp, M., and Song, C.S. Niacin Reduces Paraquat Toxicity for Rats. Science 212:1510-1512 (1981).

(45)   Heitkamp, M. and Brown, O.R. Paraquat Toxicity:  Inhibition of NAD Biosynthesis in Escherichia coli. Biochimica et Biophysica Acta 676:345-349 (1981).

(46)  Seither, R.L. and Brown, O.R. Induction of Stringency by Hyperoxia in Escherichia coli. Cellular and Molecular Biology 28:285-291 (1982).

(47)  Heitkamp, M. and Brown, O.R. Specific, Cellular Mechanisms of Paraquat Toxicity. Technical Papers of the Bureau of Sports Fisheries and Wildlife,107.  Impact of Xenobiotic Chemicals on Microbial Ecosystems, B.T. Johnson, ed., U.S. Dept. of Interior, Fish and Wildlife Service, Washington, D.C., 29-36 (1982).

(48)  Brown, O.R. and Seither, R.L. Oxygen and Redox-Active Drugs: Shared Toxicity Sites. Fundamental and Applied Toxicology 3:209-214 (1983).

(49) Seither, R.L. and Brown, O.R. Toxicity of Paraquat and Nitrofurantoin via Induction of Genetic Stringency. J. Tox. and Environ. Health 14:763-771 (1984).

(50)  Brown. O.R. Biology of Oxygen Radicals:  An Overview. In New Perspectives in Veterinary Pharmacology and Therapeutics, Proc. 5th Biennial Symposium ed. by A. Allert and Richard Adams, pp. 190-199 (1987).

(51)  Brown, O.R., Amash, H.S., Perkins, W.E. and Schroder, R.L. Doxorubicin Decreases Cardiac Pyridine Nucleotide Coenzymes in the Bertazzoli Mouse Model. Medical Science Research 15:563-565 (1987).

(52)  Smyk-Randall, E.M. and Brown, O.R. A Reverse-Phase High-Performance Liquid Chromatography Assay for Dihydroxyacid Dehydratase. Analytical Biochemistry 164:434-438 (1987).

(53)  Brown, O.R. and Green, T.J. Oxidant-Stress:  A Possible Approach to Malaria Chemotherapy. Medical Science Research 15:563-565 (1987).

(54)  Laughlin, M.H., Smyk-Randall, E. M., Novotny, M.H., Brown, O.R. and Adams, H.R. Coronary Blood Flow and Cardiac Adenine Nucleotides in Escherichia coli Endotoxemia in Dogs:  Effects of Oxygen Radical Scavengers. Circulatory Shock 25:173-185 (1988).

(55)  Brown, O.R. and Seither, R.L. Paraquat Inhibits NAD Biosynthesis at the Quinolinic Acid Synthetase Site. Medical Science Research 17:819-820 (1989).

(56)  Siwecki, G. and Brown, O.R. Overproduction of Superoxide Dismutase Does Not Protect Escherichia coli from Stringency-Induced Growth Inhibition by Paraquat. Biochemistry International 20:191-200 (1990).

(57)  Seither, R.L. and Brown, O.R. Paraquat Toxicity and Pyridine Nucleotide Coenzyme Biosynthesis:  A Data Correction. Free Radical Biology and Medicine 8:113-116 (1990).

(58)  Brown, O.R. Persistence of Reverse Glycolysis in Escherichia coli Poisoned by Hyperbaric Oxygen. Microbios 62:179-186, 1990.

(59)   Laughlin, M.H., Simpson, T., Smith, J.K., Sexton, W.L., Brown, O.R. and Korthuis, R.J. Skeletal Muscle Oxidative Capacity, Antioxidant Enzyme Levels and Exercise Training, J. Appl. Physiol., 68(6):2337-2343 (1990).

(60)  Brown, O.R. Mechanisms of Hyperbaric-Oxygen Inhibition of Growth and Net Biosynthesis of RNA, DNA, Protein, and Lipid in Escherichia coli. Microbios 64:135-151 (1990).

(61)  Seither, R.L. Babu, B. and Brown, O.R. Lung Contains an Inhibitor for Nicotinatemononucleotide Pyrophosphorylase of NAD Biosynthesis. Life Sciences 48:253-259 (1991).

(62)  Landreneau, R., Nawaranong, W., Laughlin, H., Ripperger, J., Brown, O.R., McDaniel, W., McKown, I. and Curtis, J. Direct CO2 Laser “Revascularization” of the Myocardium. Lasers in Surgery and Medicine 11:35-42 (1991).

(63) Draczynska-Lusiak, B. and Brown, O.R. Protein A of Quinolinate Synthetase is the site of Oxygen Poisoning of Pyridine Nucleotide Coenzyme Synthesis in Escherichia coli.  Free Radical Biology and Medicine 13:689-693 (1992).

(64)  Smyk-Randall, E., Brown, O.R., Wilke, A., Eisenstark, A and Flint, D.H. Near Ultraviolet Light Inactivation of Dihydroxy-acid Dehydratase in Escherichia coli. Free Radical Biology and Medicine 14:609-613 (1993).

(65)  Flint, D.H., Smyk-Randall, E., Tuminello, J., Draczynska-Lusiak, B. and Brown, O.R.  The Inactivation of Dihydroxy-acid Dehydratase in E. coli Treated with Hyperbaric Oxygen Occurs Because of the Destruction of its Fe-S Cluster, but the Enzyme Remains in the Cell in a Form That Can Be Reactivated.  J. Biol. Chem. 268:25547-25552 (1993).

(66)  Lusiak-Draczynska, Bozena, and Brown, O.R. Asparagine Synthetase: an Oxidant-Sensitive Enzyme in Escherichia coli.  Microbios 77:141-152 (1994).

(67)  Brown, O.R., Smyk-Randall, E., Lusiak-Draczynska, B., and Fee, J. Dihydroxy-Acid Dehydratase, a [4Fe-4S] Cluster containing enzyme in Escherichia coli:  Effect of Intracellular Superoxide Dismutase on its Inactivation by Oxidant Stress. Archives of Biochem. Biophys. 319:10-22 (1995).

(68)  Babu, B., and Brown, O.R. Quantitative Effects of Redox-Cycling Chemicals on the Oxidant- Sensitive Enzyme Dihydroxy-Acid Dehydratase. Microbios 82:157-70 (1995).

(69)  Brown, O.R., and Lusiak-Draczynska, B. Oxygen Inactivation of Quinolinate-Producing and Iron-Requiring 3-Hydroxyanthranilic Acid Oxidase: A Role in Hyperbaric Oxygen-Induced Convulsions? Redox Report 1:383-385 (1995).

(70)  Amash, H.S., Brown, O.R., Padron, V.A. Protection by Selective Amino Acid Solutions Against Doxorubicin Induced Growth Inhibition of Escherichia coli. General Pharmacology 26: 983-987 (1995).

(71) Chunsheng Xia, Juhong Dang, and Olen R. Brown. HPLC Analysis of Quinolinic Acid, a NAD Biosynthesis Intermediate, after Fluorescent Derivatization in an Aqueous Matrix.  Microbios 94:167-181 (1998).

(72)  Yuhong Dang and Olen R. Brown. Effects of Oxygen on 3-Hydroxyanthranilate Oxidase of the Kynurenine Pathway. Free Radical Biology and Medicine 25:1033-1043 (1998).

(73)  Nana Amiridze, Yuhong Dang, and Olen R. Brown. Hydroxyl Radicals Detected via Brain Microdialysis in Rats Breathing Air During Hyperbaric Oxygen Convulsions. Redox Report 4:165-170 (1999).

(74) Yuhong Dang, William Dale, and Olen R. Brown. Comparative Effects of Oxygen on Indoleamine 2, 3-Dioxygenase and Tryptophan 2, 3-Dioxygenase of the Kynurenine Pathway. Free Radical Biology and Medicine 28: 615-624 (2000)

(75) Yuhong Dang, W. E. Dale, and O. R. Brown. Effects of oxygen on Kynurenine 3-Monooxygenase Activity. Redox Report 5 (1) ( 2000).

(76) William Dale, Yuhong Dang, and Olen R. Brown. Tryptophan Metabolism through the Kynurenine Pathway in Rat Brain and Liver Slices. Free Radical Biology and Medicine 29:191-198 (2000).

(77) W. E. Dale, Yuhong Dang, Nana Amiridze, and Olen R. Brown. Evidence that Kynurenine Pathway Metabolites Mediate Hyperbaric Oxygen Induced Convulsions. Toxicology Letters 117:37-43 (2000).

(78) Brown, O. R. The hb-index, a modified h-index designed to more fairly assess author publication impact. Redox Report 17(4):176-178 (2012).

BOOK CONTRIBUTIONS:

(79)  Brown, O.R. and Stees, J.L. Oxygen Sensitivity of Radioresistant and Radiosensitive Strains of Bacteria. Fifth International Hyperbaric Congress Proceedings, Vol. II. Ed. by W.G. Trapp, E.W. Banister, A.J. Davison, and P.A. Trapp. Simon Fraser University, Burnaby 2, B.C., Canada, pp. 939-940 (1974).

(80)  Brown, O.R. and Stees, J.L. Resistance of Yeast Fatty Acid Synthetase Component Enzymes to Inactivation by Hyperbaric Oxygen. Fifth International Hyperbaric Congress Proceedings, Vol. I. Ed. by W.G. Trapp, E.W. Banister, A.J. Davison, and P.A. Trapp.  Simon Fraser University, Burnaby 2, B.C., Canada, pp. 172-182 (1974).

(Unnumbered: See Note immediately below) Brown, O.R., Yein, F., and Boehme, D. Bacterial Sites of Oxygen Toxicity Potentially Common to Red Cells and Erythropoiesis. The Red Cell, Proceedings 4th International Conference on Red Cell Metabolism and Function, Ed. by G.J. Brewer, Alan R. Liss, Pub., pp. 701-714 (1978). [Note: this paper is not numbered because although it is a book contribution it has been listed as a publication in my record with Harzing; therefore, I have listed it in the prior section and keep it here also because it is a book contribution.]

(81)  Brown, O.R. Cellular Sites of Oxygen Toxicity.  Proceedings of the 6th International Congress on Hyperbaric Medicine, Ed. by G. Smith, Aberdeen University Press, pp. 18-21 (1979).

(82)  Brown, O.R. Specific Enzymatic Sites and Cellular Mechanisms of Oxygen Toxicity. Biochemical and Clinical Aspects of Oxygen, edited by W.S. Caughey, pp. 755-766, Academic Press, NY (1979).

(83)  Brown, O.R., Seither, R.L., Song, C.S., Heitkamp, M.A., and Amash, H.S. Mechanisms of Toxicity of Hyperbaric Oxygen and Redox-Active Chemicals. Hyperbaric Medicine: Proceedings of the VII International Congress, edited by S.N. Yefuni, Nauka Publishing Office, Moscow, Vol. 2:116-120 (1983).

LABORATORY MANUALS:

(84)  Engley, F.B., Jr., Goldberg, H.S., Barrett, J.T., Durand, D.P, and Brown, O.R. Advanced Laboratory Manual for Medical Microbiology, Lucas Brothers Publishers, Columbia, Missouri (1965).

(85)  Engley, F.B., Jr., Goldberg, H.S., Barrett, J.T., Durand, D.P., and Brown, O.R. Elementary Laboratory Manual for Medical Microbiology, Lucas Brothers Publishers, Columbia, Missouri (1965).

(86) Brown, O.R. Laboratory Manual for Veterinary Microbiology.  Lucas Brothers Publishing Co., Columbia, Missouri (1973).

ABSTRACTS, LETTERS:

(87)  Brown, Olen R. and Clark, J.B. The pentose cycle in Nocardia corallina. Bacteriol. Proc. 16:116 (1963).

(88)  Brown, Olen R. Metabolism, Morphogenesis and Pigmentation in Nocardia corallina. Dissertation Abstracts, 64-1 (1964).

(89)  Brown, Olen R., Stees, J.L., Mills, D.F., and Davis, R. Effects of Hyperoxia Upon Microorganisms. Trans. Missouri Acad. Sci. 2:118 (1968).

(90)  Brown, Olen, R. Mechanisms of Oxygen Toxicity at the Cellular Level. ONR Report DR-146, pp. 50-51. Microbiology Program Code 440, Office of Naval Research, Arlington, Virginia (1969).

(91)  Howitt, H.F. and Brown, O.R. Inhibition of Fatty Acid Synthesis in Escherichia coli by Oxygen at High Pressure. Trans. Missouri Acad. Sci. 3:100 (1969).

(92)  Brown, O.R. Survival of Bacterial Cells in Hyperoxic Environments. In:  Extreme Environments, Mechanisms of Microbial Adaptation, p.50. NASA-Ames Res. Center, Moffett Field, California (1970).

(93)  Brunker, R.L. and Brown, O.R. Effects of Hyperoxia on Oxidized and Reduced NAD and NADP in Escherichia coli. In: Aerospace Medical Pre-prints of Scientific Program, pp. 100-101. Aerospace Medical Association, Washington National Airport, Washington, D.C. (1970).

(94)  Brown, O.R. Mechanisms of Oxygen Toxicity at the Cellular Level. Progress Report Abstracts pp. 49-50. Microbiology Program Code 440, Office of Naval Research, Arlington, Virginia (1970).

(95)  Brown, O.R. Correlations Between Sensitivity to Radiation and Hyperoxia in Microorganisms. Trans. Missouri Acad. Sci., 5:131 (1971).

(96)  Brown, O.R. Mechanisms of Oxygen Toxicity at the Cellular Level. ONR Report ACR-174, pp. 49-50. Microbiology Program Code 440, Office of Naval Research, Arlington, Virginia (1971).

(97)  Stees, J.L. and Brown, O.R. Effects of Hyperoxia on Fatty Acid Synthetase. Fifth Symposium on Underwater Physiology Pre-prints, p. 79 (1972).

(98)  Brown, O.R. Mechanisms of Oxygen Toxicity at the Cellular Level. ONR Report ACR-180, pp. 19-20. Microbiology Program Code 440, Office of Naval Research, Arlington, Virginia (1972).

(99)  Brown, O.R. Relationships Between Radiation Sensitivity and Oxygen Toxicity at the Cellular Level. Trans. Missouri Acad. Sci. (1973).

(100)  Brown, O.R. Mechanisms of Oxygen Toxicity at the Cellular Level. ONR Report ACR-189, pp. 93-94. Microbiology Program Code 440, Office of Naval Research, Arlington, Virginia (1973).

(101)  Brown, O.R. Inhibition of Membrane Transport by Hyperoxia. Undersea Biomedical Research 1:A16-17 (1974).

(102)  Brown, O.R. Mechanisms of Oxygen Toxicity at the Cellular Level. Progress Report Abstracts, ONR Report ACR-212, pp. 29-30. Microbiology Program Code 440, Office of Naval Research, Arlington, Virginia (1975).

(103)  Brown, O.R., Boehme, D.E., and Vincent, K. Inhibition of Biosynthesis of Branched-Chain and Aromatic Amino Acids by Hyperbaric Oxygen. Undersea Biomedical Research 3:A33 (1976).

(104)  Brown, O.R., Boehme, D.E., and Yein, F. Inhibition of Synthesis of NAD and Thiamine as Potential Primary Sites of Cellular Oxygen Toxicity. Preprint, 48th Ann. Meeting, Aerospace Med. Assoc. (1977).

(105)  Brown, O.R. and Yein, F. Role of the “Stringent Response” in O2-Inhibition of Protein, RNA, and DNA Synthesis. Undersea Biomed. Res. 4:A18 (1977).

(106)  Seither, R. and Brown, O.R. Induction of Stringency by Hyperbaric Oxygen. Annual Meeting of the American Society of Microbiology K97, p. 142 (1980).

(107)  Heitkamp, M.A. and Brown, O.R. Paraquat Poisoning of Nicotinamide Adenine Dinucleotide Synthesis. Trans. Mo. Acad. Sci. 14:182 (1980).

(108)  Song, C.S. and Brown, O.R. Pyridine Nucleotide Coenzyme Biosynthesis:  A Cellular Site of Oxygen Toxicity. Trans. Mo. Acad. Sci. 14:182 (1980).

(109)  Seither, R. and Brown, O.R. Induction of Stringency in Escherichia coli by Hyperoxia. Trans. Mo. Acad. Sci. 14:183 (1980).

(110)  Heitkamp, M., Brown, O.R., and Johnson, T. Paraquat Poisoning of NAD Biosynthesis, K-113, p. 156. Annual Meeting of the Amer. Soc. Microbiol. (1981).

(111)  Seither, R.L. and Brown, O.R. Hyperbaric Oxygen and Redox Active Drugs:  A Common Mechanism of Toxicity. Trans. Mo. Acad. Sci. 15:241 (1981).

(112)  Amash, H.S. and Brown, O.R. Similarities between the Mechanisms of Oxygen Toxicity and Radiation Induced Damage in Stringent and Relaxed Strains of Escherichia coli. Trans. MO. Acad. Sci. 15:242 (1981).

(113)  Amash, H. and Brown, O.R. Inhibition of Amino Acid Biosynthesis:  A Common Mechanism of Toxicity Between Adriamycin and Hyperbaric Oxygen in Escherichia coli. Annual Meeting of the Amer. Soc. for Microbiol. A15 (1982).

(114)  Brown, O.R., Seither, R.L., Song, C.S., Heitkamp, M.A. and Amash, H.S.

Mechanisms of Toxicity of Hyperbaric Oxygen and Redox-Active Chemicals. VII International Congress of Hyperbaric Medicine, Moscow, USSR, Sept. 2-6, 1981.

(115)  Brown, O.R. and Stebbins, N.E. Paraquat Poisoning in the Common Pathway of Aromatic Amino Acid Biosynthesis in Escherichia coli. Annual Meeting MO Valley Society for Microbiology 22 (1986).

(116)  Smyk-Randall, E.M. and Brown, O.R. Inhibition of Dihydroxyacid Dehydratase in Branched-Chain Amino-Acid Biosynthesis by Paraquat and Other Oxidant Stressors, Missouri Branch, American Society for Microbiology, Osage Beach, Missouri, S-11 (1987).

(117)  Filippelli, F., Stebbins, N., and Brown, O.R. Effects of Paraquat on Aromatic Amino Acids Biosynthesis in Escherichia coli, Missouri Branch, American Society for Microbiology, Osage Beach, Missouri, S-10 (1987).

(118)  Smyk-Randall, E.M. and Brown, O.R. Inhibition of Dihydroxyacid Dehydratase in Branched-Chain Amino-Acid Biosynthesis by Redox-Active Compounds. Trans. Missouri Acad. Sci. 21:163 (1987).

(119)  Brown, O.R., Smyk-Randall, E.M., Novotny, M.J., Laughlin, M.H., and Adams, H.R. Effects of Dferoxamine, Catalase, Superoxide Dismutase, and Allopurinol on the Myocardial Response to Gram-Negative Endotoxemia. American Heart Association, Durango, Colorado (1987).

(120)  Smyk-Randall, E.M. and Brown, O.R. Paraquat and Other Oxidant Stressors Inhibit Dihydroxyacid Dehydratase of Branched-Chain Amino Acid Biosynthesis.  21st Mid-Atlantic Regional Meeting, American Chemical Society May 19-21, No.16 p. 43 (1987).

(121)  Laughlin, M.H., Simpson, T., Smith, J.K., Brown, O.R., Sexton, W. and Korthuis, R.J. Relationship Between Oxidative Capacity and Antioxidant Enzyme Levels in Rat Skeletal Muscles. The Physiologist 31:A39 (1988).

(122)  Landreneau, R., Nawarawong, N., Laughlin, H., McDaniel, W., Brown, O., McKown, D. and Franklin, D. The Effect of CO2 Laser Revascularization on Myocardial Perfusion and Function. American Society for Laser Medicine and Surgery, Tenth Annual Meeting, April 6-8, 1989.

(123)  Smyk-Randall, E.M. and O.R. Brown. Inhibition of Dihydroxyacid Dehydratase in Branched-Chain Amino-Acid Biosynthesis by Redox-Active Compounds. Trans. Missouri Academy of Science (1989).

(124)  Brown, O.R. and Smyk-Randall, E.M. Intracellular Manipulation of SOD: Effects on an Oxidant-Sensitive Enzyme, Dihydroxyacid Dehydratase. Annual Meeting of the American Society for Cell Biology, Houston, Texas, November, 1989.

(125)  Brown, O.R. and Smyk-Randall, E.M. Cellular Superoxide Dismutase and Oxidant Stress. Free Radical Society Meeting, Tubingen, West Germany, December, 1989.

(126)  Smyk-Randall, E.M., D.H. Flint (Du Pont Corp.) and O.R. Brown. Mechanism of Reactivation of Oxidant-Inactivated Dihydroxyacid Dehydratase. FASEB, Washington,

(127)  Brown, O.R. and Draczynska-Lusiak, B. Oxidant Sensitivity of [4Fe-4S] Cluster-Containing Dihydroxy-Acid Dehydratase (VII International Congress of Toxicology, abst. # 7200).

(128)  Brown, O.R. and Draczynska-Lusiak, B. A Role for 3-Hydroxyanthranilate Oxidase in Hyperbaric Oxygen Convulsions? (VII International Congress of Toxicology, abst. # 7199).

(129)  Yuhong Dang, Chunsheng Xia, and Olen R. Brown. Effects of Oxygen on 3-hydroxyanthranilate oxidase and Quinolinic Acid Production via the Kynurenine Pathway. 2nd International Oxidative Stress and Brain Damage Symposium, Sept. 26-28, 1997. Chicago, Ill.

(130)  Olen R. Brown, Yuhong Dang and Nana Amiridze. Quinolinic Acid, Hyperbaric Oxygen Induced Convulsions and the Kynurenine Pathway. 2nd International Meeting on Oxygen/Nitrogen Radicals and Cellular Injury, Sept. 7-10, 1997, Raleigh, North Carolina.

(131)  Ramanathan, Ragu, O.R. Brown, Dil Peiris, Yuhong Dang and Nana Amiridze. Detection and Characterization of in vivo Formed Tryptophan and Metabolites by Using LC-ESI-MS and LC-ESI-MS/MS. American Society for Mass Spectrometry, 1998 meeting.        

(132) Dale, William E., Nana Amiridze, Yuhong Dang, and O. R. Brown. Brain Hydroxyl Radicals During Hyperbaric Oxygen Convulsions. 5th Annual Meeting of the Oxygen Society, Nov. 19-23, 1998, Washington, D.C.

(133) Dale, William E., Yuhong Dang, and O. R. Brown. Oxygen and Indoleamine or Tryptophan 2, 3 Dioxygenase of the Kynurenine Pathway. 6th Annual Meeting of the Oxygen Society, Nov., 1999.

(134)  Dale, William E., Yuhong Dang, and O. R. Brown. Hyperbaric Oxygen and Kynurenine Pathway Intermediates. 6th Annual Meeting of the Oxygen Society, Nov., 1999.

FREE-LANCE:

(135)  Brown, O.R. Enlist a Billion Friends to Control Your Bagworms. Organic Gardening & Farming (1974).

(136)  Brown, O.R. Outsmarting the Mole. The Almanac for Farmers & City Folks, Edited by Lucas McFadden, 68-70 (1998).

PUBLISHED CRITICAL BOOK and FILM REVIEWS:

(137)  The Unfinished Universe by Louise B. Young, Simon and Schuster, N.Y. (1986); Appeared in Science Books and Films, ed. by K.S. Johnson, vol. 23, pp. 205 (1987). American Association for the Advancement of Science, Washington, D.C.

(138)  What To Do About AIDS:  Physicians and Mental Health Professionals Discuss the Issues (Illus.). Edited by McKusick, L. Berkeley, University of California Press (1986); ibid, vol. 23, pp. 19-20 (1987).

(139)  The Therapeutic Touch:  A New Skill from an Ancient Practice; Presenter, T.C. Mechan, Video by Hospital Satellite Network (1986). Ibid, vol. 21, pp. 156 (1986).

(140)  The Comparative Reception of Darwinism, edited by Thomas F. Glick, The University of Chicago Press, Chicago and London (1988); ibid, vol. 24, pp. 279 (1989).

(141)  The Darwinian Paradigm:  Essays on its History, Philosophy and Religious Implications by Michael Ruse, Routledge Publishing Co., London and New York (1989); ibid, vol. 25, pp. 16-17 (1989).

(142)  Science and Medicine in the Old South by Ronald L. Savitt, Louisiana State University Press (1989). Appeared in Science Books and Films, ed. by Maria Sosa and Nancy van Gorden, vol. 25, p. 252 (1990), American Association for the Advancement of Science, Washington,

(143)  Body Clock:  The effects of time on human health by Martin Hughes (Ed.), Andromeda Oxford Ltd. (1989); ibid, vol. 6 #1, p. 41 (1990).

(144)  Ending The HIV Epidemic, Community Strategies in Disease Prevention and Health Protection by Steven Petrow (Ed.), In association with San Francisco AIDS Foundation, Institute for Health Policy Studies, and The Center for AIDS Prevention Studies, Univ. of Calif., San Francisco, Network Publications, a division of ETR Associates, Santa Cruz, CA (1990); ibid, vol. 27 #1, p. 8 (1991).

(145)  Piltdown:  A Scientific Forgery (Illus.) by Frank Spencer. Oxford University Press (1990); Ibid, vol. 27 #2, p. 39 (1991).

(146)  Interpreting Evolution:  Darwin and Teilhard de Chardin, (Illustrated) by James H. Brix. Prometheus Books, Buffalo, New York (1991). Appeared in Science Books and Films, ed. by Maria Sosa, vol. 27 #4, p. 101 (1991), American Association for the Advancement of Science, Washington, D.C.

(147)  The Third Chimpanzee:  The Evolution and Future of the Human Animal, by Jared Diamond. Harper Collins, New York, NY (1992); ibid, Maria Sosa, vol. 28#4, pp. 102-103 (1992).

(148)  Part 1:  Structure of the Cell (Color Video), Clearvue-EAV, 6465 N. Avondale Ave., Chicago, IL (1992); and ibid, vol. 28#4, pp. 118-119 (1992).

(149)  Part 2:  Evolution of the Cell (Color Video), Clearvue-EAV, 6465 N. Avondale Ave., Chicago, IL (1991); and ibid, vol. 28#4, pp. 118-119 (1992).

(150)  Heart Attack:  Every Minute Counts (Color Video), Milner-Fenwick, Inc., 2125 Greenspring Drive, Timonium, Md. (1992); ibid, vol. 29#2, p. 56 (1993).

(151)  Genes and the Biology of Cancer, by Harold Varmers and Robert A. Weinberg. Freeman, NY (1992); ibid, vol. 29#2, p. 46 (1993).

(152)  Getting Here:  The Story of Evolution. (Illus.) Washington, D.C.: Compass Press (1993). Appeared in Science Books and Films, ed. by Maria Sosa, Tracy Gath, and Chickona Royster, vol. 29#7, p. 198 (1993), American Association for the Advancement of Science, Washington, D.C.

(153)  From So Simple A Beginning, The Book of Evolution. (Illus.) by Philip Whitfield. Macmillan Publishing Company, N.Y. (1993). Appeared in Science Books and Films, ed. by Maria Sosa and Tracy Gath, vol. 30#4, p. 108 (1994), American Association for the Advancement of Science, Washington, D.C.

(154)  Incredible Edible Science (Illus.) by Lynne Brunelle (a Scientific American Mysteries of Science book). Scientific American Books for Young Readers, N.Y. (1994); ibid, vol. 30#8, p. 242 (1994).

(155)  Evolution by Association: A History of Symbiosis by Jan Sapp.  Oxford University Press, N.Y. (1994); ibid, vol. 31#3, p. 76(1995).

(156)  Darwins Dangerous Idea: Evolution and the Meanings of Life (Illus.) by Daniel C. Dennett. Simon and Schuster, N.Y. (1995); ibid, vol. 31 #7, pp.196-197(1995).

(157)  Evolution on Trial (Illus., from the Perspectives on History Series) by Ellen Hansen, Ed., Carlisle, MA: Discovery Enterp., Ltd. (1995); ibid, vol. 32 #1, p. 12 (1996).

(158)  The Ingenious Mind of Nature: Deciphering the Patterns of Man, Society and the Universe (Illus.) by George M. Hall. NY: Plenum Press (1997); ibid, Vol. 33#9, p. 260 (1997).

(159)   From Devil’s Disciple to Evolution’s High Priest. (Illus.) by Adrian Desmond. NY: Addison-Wiley (1997); ibid, vol. 34#3, p. 72 (1998).

(160) The Greatest Benefit to Mankind: A Medical History of Humanity (Illus.), NY: Norton (1998), ibid, vol. 34#8, p. 240 (1998).

(161) Confessions of a Medicine Man: An Essay in Popular Philosophy. (Illus.) Cambridge, MA: MIT Press, 1999, xviii + 159 pp., Alfred I. Tauber. ibid, vol. 35#4, p. 154 (1999).

(162) Aspects of Protein Structure: The Role of Individual Amino Acids in Structure and Function, by A. T. Hagler, J. S. Fetrow, and D. Mackay.  Computer disk designed by ScienceMedic.com, 6540 Lusk Blvd., Suite C148, San Diego, CA (1999), ibid, vol. 36#1, pp. 43-44 (2000).

(163) Secret Agents: The Menace of Emerging Infections, Washington DC: Joseph Henry Press, 2002, 300pp. Madeline Drexier. ibid.

(164) The Cruelest Miles, the Heroic Story of Dogs and Men in a Race against an Epidemic (Illus.), by Gay Salisbury and Laney Salisbury. W. W. Norton and Company, New York, London (2003); ibid, vol. 39#6, p. 269 (2003).

(165) SARS: The True Story. Films for the Humanities and Sciences. A video about the emergence of SARS (severe adult respiratory syndrome, caused by a coronavirus). Julie Hall of the WHO’s (World Health Organization) Global Alert, Response, and Operations Department, and WHO virologist Klaus Stohr and other personnel are featured in this BBCW Production (2004); ibid, vol. 40#4, p. 184 (2004).

(166)  Stories of Lupus. Fanlight Productions, Big Rapids, MI. Video produced by Marcia Urbin-Raymond and Karin Millberg. ibid (2005).

(167)  What Is Cancer? Films for the Humanities and Sciences, Inc., Box 2053, Princeton, NJ 08543-2053 (2004)/ (From the Cancer Story Series.) Color, 57 min, DVD/VHS. Ibid vol 41(5) p 230 (2005).

(168) Christine and Paul: A Journey with Alzheimer’s Disease. Video produced by NHK, Filmakers Library, 124 E. 40th Street, NY, NY 10016.(Ibid.

(169) The Asthma Update. Alvin and Virginia Silverstein and Laura Silverstein Nunn: One of a series of medical updates including diabetes, tuberculosis, STDs, Flu and pneumonia (Ibid. volume 42#5, p. 221-222 (2006).

(170) Influenza the Next Pandemic by Connie Goldsmith.Twenty-First Century Medical Library, Twenty-First Century Books, Minneapolis (2007); Ibid.

(171) Richard Walker: Epidemics and Plagues. Kingfisher, 2007. Ibid.

(172) The Breast Cancer Update. Alvin and Virginia Silverstein and Laura Silverstein Nunn, Enslow Publishers, Inc. 40 Industrial Road, Box 398, Berkeley Heights, NJ 07822 (2008). Ibid.

(173) Jerald Winakur: Memory Lessons, A Doctor’s Story. Hyperion. Ibid.

(174) Jonathan  A. Edlow, M.D. The Deadly Dinner Party: and Other Medical Detective Stories. New Haven, CT: Yale, 2009. Xiii+245 pp. Ibid.

(175) Jonathan Weiner: Long for this World. The Strange Science of Immortality. CCC an Imprint of Harper Collins Publishers NY, 2010 310 pp, ISBN 9780060765361. Ibid.

(176)  de Duve, Christian, with Neil Patterson, forward by Edward O. Wilson. Genetics of Original Sin: The Impact of Natural Selection on the Future of Humanity. (Illus.) New Haven, Ct: Yale, 2010. xxvii+223 pp. ISBN 9780300165074. Ibid. (2010).

(177) Canadian Broadcasting Corporation, Killed by Care: Making Medicine Safe. Icarus Films, 32 Court St., 21st Floor, Brooklyn, NY 11201 (2004), 47 min., DVD, color, closed captioned. Ibid. Vol. 48#5, p. 135m May (2012).

(178) Quammon, David. Spillover: Animal Infections and the Next Human Pandemic. NY: Norton, 2012. 554 pp. ISBN 9780393066807. Ibid. Vol. 48#9, Sept. pp. 245-246 (2012).

(179) Rotner, Shelly and David A. White. Body Actions (Illus.) NY: Holiday House, 2012. 32pp. Ibid, Vol. 49#2, Feb. p. 45 (2013).

(180) Kyi, Tanya Lloyd. Seeing Red: The True Story of Blood. (Illus. by Steve Rolston.) Willowdale, ON: Annick Press, 2012. 122pp. Ibid, Vol. 49#2, Feb. pp. 44- 45 (2013).

(181) Nutter, Francine Mary. Medicine’s Michelangelo: The Life and Art of Frank H. Nutter, MD. (Illus.) Hamden, CT: Quinnipec University Press, 2013, 488 pp. IBSN978098913. Ibid, Vol. 49#2 p. 263, Dec. (2013).

(182) Agar, Nicholas. Truly Human Enhancement. MIT Press (E-Book) 232 pp (6” x 9” with 4 Figs.) ISBN 9780262318969. Dec. (2013). Ibid, Vol. 51#1, p. 21, Jan. (2015).

(183) Brown, Pat. The Murder of Cleopatra: History’s Greatest Cold Case. (Illus.) Amherst, NY: Prometheus, 264 pp, ISBN 9781616146504 (2013). (Ibid, In Press).

(184) Shlain, Leonard. Leonardo’s Brain. Understanding DaVinci’s Creative Genius. Lyons Press, 240 pp. Published Oct 7 (2014). Ibid, Vol. 51#1, p. 24 (Jan. 2015).

(185) Nilsson, Nils J. Understanding Beliefs. MIT Press (E-Book) 168 pp (5” x 7” with 5 Figs.) ISBN 9780262526432.  August (2014). (Ibid, In Press).

(186) Anon. Superlife: Genetic Manipulation Series. Color DVD. 52 min. Super Foods Film Ideas, Inc., 308 N. Wolf Road (2014). (Ibid, In Press).

(187) Anon. The Placebo Effect. Color DVD. 52 min. Film Ideas Inc., 308 N. Wolf Road. (2015) (Ibid, In Press).

(188) Anon. The True Cost. Bullfrog Films. 2015. Color, 92 min. DVD SDH captioned. (Ibid, In Press).

(189) Anon. Lunch Love Community. 2014. Color, 78 min. DVD. Closed Captioned. (2016). (Ibid, In Press).

(190) Wilson, David Sloan. Does Altruism Exist? Culture Genes and the Welfare of Others. New Haven, CT: Yale, 224 pp. ISBN 9780300189490. (2015). (Ibid, In Press).

(191) Canavan, Roger. Bacteria! (Illus. by Mark Bergin: from the You Wouldn’t Want to Live Without Series.) NY: Scholastic, 32 pp. ISBN 9780531214060. (2015) . (Ibid, In Press).

(192) Macdonald, Fiona. Dentists! (Illus. by David Antram: from the You Wouldn’t Want to Live Without Series.) NY: Scholastic, 32 pp. ISBN 9780531214107 (2015). (Ibid. In Press).

(193) Rooney, Ann. Vaccinations! (Illus. by David Antram: from the You Wouldn’t Want to Live Without Series.) NY: Scholastic, 32 pp. ISBN 9780531214091 (2015). (Ibid. In Press).

(194) Shar, Sonia. Pandemic: Tracking Contagion, from Cholera to Ebola and Beyond. NY: Farrar, Straus, and Giroux,  271 pp. ISBN 9780374122881 (2 016). (Ibid, In Press).

(195) Murphy, Jim. Breakthrough! How Three People Saved “Blue Babies” and Changed Medicine Forever. Clarion Books, Houghton Mifflin Harcourt, Boston, New York. ISBN 9-780547-821832. 130 pp. (reviewed, 2017).

(196) Lamb, Jonathan. Scurvy: The Disease of Discovery. Princeton University Press, 2016. 328 pp. ISBN 9780691147826; (reviewed November 26, 2017).

(197) Georget, Anne. Cholesterol: The Great Bluff. 82 min., in color, 2016. Icarus Films, 32 Court Street, 21st Floor, Brooklyn, NY 11201. In the Press 2018.

(198) Georget, Anne. Cholesterol: The Great Bluff. 82 min., in color, 2016. Icarus Films, 32 Court Street, 21st Floor, Brooklyn, NY 11201. In the press 2018.

(199) Sarah Albee. Poison, Deadly deeds, perilous professions, and murderous medicines.ISBN 978-1-101-93223-0. Crown Books, New York. In the press, 2018.  

BOOKS : 

(200)  Brown, O. R. The Art and Science of Expert Witnessing, Cypress Publishing Group, Leawood, KS, March 23, 2002. (Description and 2 chapters viewable on Cypress Publishing Group’s website.)

(201) Brown, O. R. Miracles, BookSurge Publishing, April, 2007.

(202) Brown, O. R. Oxygen, the Breath of Live: Boon and Bane in Human Health, Disease, and Therapy. 356 pp. March, 2017, Bentham-Elsevier. IBSN 978-1-68108-426-8.

(203) Brown, O. R. The Art and Science of Poisons. ISBN 978-1-68108-698-9. May 2018, Bentham-Elsevier.

This episode first aired on Nov 17, 2018.

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